N,2-Dihydroxybenzamide 水杨羟肟酸

CAS 89-73-6 MFCD00002110

化学结构图

89-73-6
SMILES: O=C(NO)c1ccccc1O

化学属性

Mol. FormulaC7H7NO3
Mol. Weight153
Density1.422
Melting Point177
TSCANo
Appearance 白色针状结晶。熔点168℃(缓慢加热),176-178℃(急热)。溶于醇和醚,能升华。在空气中逐渐渐变红。

别名和识别编码

Chemical NameN,2-Dihydroxybenzamide
CAS Number89-73-6
Alfabeta NameSALICYLHYDROXAMICACID
MDL NumberMFCD00002110
Synonym 2-Hydroxybenzenehydroxamic acid 2-Hydroxybenzohydroxamic 2-Hydroxybenzohydroxamic Acid 2-Hydroxybenzohydroxamic acid o-Hydroxybenzohydroxamic acid Benzamide, N,2-dihydroxy- LABOTEST-BB LT00454000 N,2-Dihydroxy-benzamide N,2-dihydroxybenzamide N-HYDROXYSALICYLAMIDE N-羟基邻羟基苯甲酰胺 Salicylhydroxamic Salicylhydroxamic acid Salicylhydroxamicacid,99% Salicylohydroxamic acid Salicylohydroximic acid n,2-dihydroxy-benzamid nsc5088 o-hydroxybenzohydroxamicacid sha 水杨基氧肟酸 水杨氧肟酸,水杨酰异羟肟酸,邻羟基苯甲酰异羟肟酸 水杨酰异羟肟酸 水杨酰肟酸 水杨酰胺肟 水杨酸肟酸 水杨醛肟酸
EC Number201-934-3
Beilstein Registry Number10,98
Merck Number8331
PubChem Substance ID87575639
Reaxys-RN1210520
Chemical Name Translation水杨羟肟酸
Wiswesser Line NotationQMVR BQ
LabNetwork Molecule IDLN00176277
InChIInChI=1S/C7H7NO3/c9-6-4-2-1-3-5(6)7(10)8-11/h1-4,9,11H,(H,8,10)
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分类

  • Pharmaceuticals
  • {uni_hamburg} no charge; carbocycle; aromatic; 6RingOnly; 6ring; amide; alcohol; 1fragment
  • Aromatics
  • Intermediates & Fine Chemicals
  • {SNA} Building Blocks, Chemical Synthesis, Hydroxylamines, Nitrogen Compounds, Organic Building Blocks

产品应用

  • 医药中间体。化学分析沉淀剂,分析铋、铜、镍和铜的试剂。
  • 水杨羟肟酸能与锡、钨、稀土、铜、铁等金属形成稳定的螯合物,而与碱土金属及碱金属形成不稳定的螯合物,所以,水杨羟肟酸具有较好的选择性。特别是水杨羟肟酸与锡石螯合时不仅能形成多种形式的外络盐,而且还能形成不同构成的内络盐,因此,水杨羟肟酸对锡的选择性较强。该品在锡石选矿中通常与P86配套使用,并具有一定的起泡性。

相关文献及参考

  • Peebles, C., et al.: Biotechnol. Bioeng., 103, 1248 (2009),
  • Merck: 14,8331 Beilstein:10,98
  • Short: EINECS
  • Short: III/31a
  • Neeley, E., et al.: Int. J. Mol. Sci., 10, 3811 (2009),
  • Singh, A., et al.: J. Biol. Chem., 284, 20311 (2009),
  • Merck: 14,8331

安全信息

Warnings IRRITANT
Signal word Warning
GHS Symbol
WGK Germany3
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘;
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
Risk Statements
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
  • R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P352+P332+P313+P362+P364
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P308+P313
  • P332+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
RTECSVO6870000
Hazard Codes Xn
Hazard statements
  • H303 May be harmfully swallowed 吞食可能有害
  • H312 Harmful in contact with skin 皮肤接触有害
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H332 Harmful if inhaled 吸入有害
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H351 Suspected of causing cancer 怀疑致癌
Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TOLED5 Toxicology Letters.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1977-  Volume(issue)/page/year:
   (Suppl),247,1992

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 600 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TOLED5 Toxicology Letters.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1977-  Volume(issue)/page/year:
   (Suppl),247,1992

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 860 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCISP* National Cancer Institute Screening Program Data Summary,
   Developmental Therapeutics Program. (Bethesda, MD 20205)
   Volume(issue)/page/year: JAN1986

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 1 mg/plate
REFERENCE :
   AMACCQ Antimicrobial Agents and Chemotherapy.  (American Soc. for
   Microbiology, 1913 I St., NW, Washington, DC 20006)  V.1-    1972-
   Volume(issue)/page/year: 11,753,1977

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 1 mmol/L
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   29,1275,1980

其他信息

  • 用途二:医药中间体。化学分析沉淀剂,分析铋、铜、镍和铜的试剂。水杨羟肟酸能与锡、钨、稀土、铜、铁等金属形成稳定的螯合物,而与碱土金属及碱金属形成不稳定的螯合物,所以,水杨羟肟酸具有较好的选择性。特别是水杨羟肟酸与锡石螯合时不仅能形成多种形式的外络盐,而且还能形成不同构成的内络盐,因此,水杨羟肟酸对锡的选择性较强。该品在锡石选矿中通常与P86配套使用,并具有一定的起泡性。
  • MOL 文件:89-73-6.mol
  • Sigma Aldrich:89-73-6(sigmaaldrich)
  • 上游原料:水杨酸甲酯
  • MSDS 信息:2-Hydroxybenzohydroxamic acid(89-73-6).msds
  • 水杨羟肟酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 xw010091 水杨异羟肟酸 100g 1200元 2011/04/16 S0008 水杨基羟肟酸 Salicylhydroxamic Acid 5G 262元 2011/04/16 S0008 水杨基羟肟酸 Salicylhydroxamic Acid 25G 676元
  • 用途一:医药中间体。化学分析沉淀剂,分析铋、铜、镍和铜的试剂。
  • TCI Shanghai:水杨基羟肟酸 Salicylhydroxamic Acid,>;98.0%(T)(89-73-6)
  • Alfa Aesar:水杨基异羟肟酸,99% Salicylhydroxamic acid, 99%(89-73-6)
  • 溶于醇和醚,能升华。在空气中逐渐渐变红。
  • 图谱信息:水杨羟肟酸(89-73-6)质谱(MS) 水杨羟肟酸(89-73-6)红外图谱(IR2) 水杨羟肟酸(89-73-6)红外图谱(IR1) 水杨羟肟酸(89-73-6)核磁图( 1 HNMR)
  • 方法一:由邻羟基苯甲酸甲酯与盐酸羟胺在氢氧化钠存在下缩合,再经酸化而得。

系列性分类


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