Acetohydroxamic Acid 乙酰氧肟酸

CAS 546-88-3 MFCD00009994

化学结构图

546-88-3
SMILES: CC(=O)NO

化学属性

Mol. FormulaC2H5NO2
Mol. Weight75.07
Melting Point88-90°C
TSCANo
Density1.155
Stability易吸潮,对光敏感
Boiling Point231.4°C at 760 mmHg

别名和识别编码

Chemical NameAcetohydroxamic acid
CAS Number546-88-3
Alfabeta NameACETOHYDROXAMICACID
MDL NumberMFCD00009994
Synonym Acetohydroxamic acid {LY} Acetohydroxamic acid Lithostat N-hydroxyacetamide N-hydroxyacetamidine Uronefrex acetohydroxamic acid {} {LY} Acetohydroxamic acid {} {} {LY} Acetohydroxamic acid {} {} {} {LY} Acetohydroxamic acid {} {} {} {} {LY} Acetohydroxamic acid {} {} {} {} {} {LY} Acetohydroxamic acid {} {} {} {} {} {} {LY} Acetohydroxamic acid {} {} {} {} {} {} {} {LY} Acetohydroxamic acid {} {} {} {} {} {} {} {} {LY} Acetohydroxamic acid {} {} {} {} {} {} {} {} {} {LY} Acetohydroxamic acid {} {} {} {} {} {} {} {} {} {} {LY} Acetohydroxamic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Acetohydroxamic acid {} {} {} {} {} {} {} {} {} {} {} {} {LY} Acetohydroxamic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Acetohydroxamic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Acetohydroxamic acid {} {} {} {} {} {} {} {} {} {} {} {} {}
PubChem Substance ID1990
EC Number208-913-8
Beilstein Registry Number1739019
Reaxys-RN1739019
Merck Number63
Chemical Name Translation乙酰氧肟酸
Wiswesser Line NotationQMV1
LabNetwork Molecule IDLN00001754
InChIInChI=1S/C2H5NO2/c1-2(4)3-5/h5H,1H3,(H,3,4)
Canonical SMILESCC(NO)=O
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分类

  • {SNA} Analytical S
  • {SNA} A-AM, Building Blocks, Chemical Synthesis,
  • {SNA} Building Blocks, Chemical Synthesis, Hydroxylamines, Nitrogen Compounds, Organic Building Blocks
  • Inhibitors
  • {SNA} Analytical Standards, Chromatography, Pharmaceutical Standards, Pharmacopeia Standards, USP Standards, USP Standards

产品应用

  • 本品医药上是尿酶竞争抑制剂,用于尿肾结石等病症治疗;牧业上用于提高饲料蛋白质转化率 。也用于制备其它药物。

相关文献及参考

  • Short: III/35E
  • Short: III/31a
  • Xiao, Z.-P., et al.:
  • Merck:14,63 Beilstein:2,187
  • Merck:14,63

安全信息

Warnings IRRITANT
GHS Symbol
WGK Germany3
Hazard statements
  • H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges Eyeshields, Gloves, type P2 (EN 143) respirator cartridges
Hazard Codes T
RTECSAK8157000
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
  • P203
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P308+P313
  • P318
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S53 Avoid exposure - obtain special instructions before use 避免接触,使用前获得特别指示说明;
Risk Statements
  • R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害
Storage condition 2-8°C {LY} 2-8°C Hygroscopic {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
Packing GroupII
UN Number 3263
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 92 660,1956

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 18,645,1968

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 5 umol/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 172,199,1986

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 20 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 152,225,1985

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 160 umol/plate
REFERENCE :
   JOPHDQ Journal of Pharmacobio-Dynamics.  (Japan Pub. Trading Co. (USA), 1255
   Howard St., San Francisco, CA 94103)  V.1-    1978- Volume(issue)/page/year:
   3,557,1980

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Bacillus subtilis
DOSE/DURATION           : 250 umol/disc
REFERENCE :
   JOPHDQ Journal of Pharmacobio-Dynamics.  (Japan Pub. Trading Co. (USA), 1255
   Howard St., San Francisco, CA 94103)  V.1-    1978- Volume(issue)/page/year:
   3,557,1980

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 2500 umol/L
REFERENCE :
   PHTOEH Pharmacology and Toxicology (Copenhagen).  (Munksgaard International
   Pub., POB 2148, DK-1016 Copenhagen K, Denmark)  V.60-    1987-
   Volume(issue)/page/year: 60,9,1987

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 10 mmol/L
REFERENCE :
   PHTOEH Pharmacology and Toxicology (Copenhagen).  (Munksgaard International
   Pub., POB 2148, DK-1016 Copenhagen K, Denmark)  V.60-    19

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 750 mg/kg
SEX/DURATION            : female 12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Specific Developmental Abnormalities - eye/ear
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   JMXSAE Journal of Maxillofacial Surgery.  (Georg Thieme Verlag, Postfach
   732, D-7000 Stuttgart 1, Fed. Rep. Ger.)  1973-  Volume(issue)/page/year:
   2,230,1974

其他信息

  • Sigma Aldrich:546-88-3(sigmaaldrich)
  • 储运特性:库房通风低温干燥
  • 图谱信息:乙酰氧肟酸(546-88-3)红外图谱(IR2) 乙酰氧肟酸(546-88-3)红外图谱(IR1) 乙酰氧肟酸(546-88-3)质谱(MS) 乙酰氧肟酸(546-88-3)Raman光谱
  • 毒性分级:中毒
  • 用途一:原为USP收载用于治疗细菌性胆,肾结石及肝昏迷等症.由于良好的瘤胃微生物脲酶抑制作用,英、美等国于上世纪九十年代初始用于牛、羊等反刍动物营养,以改善瘤胃氨环境,提高蛋白质的转化率,增加粗饲料采食量,降低血液氨浓度,减轻氨应激,增加机体免疫力,收到良好效果.
  • 几乎无臭;味微苦;遇光变色;易吸潮;易溶于水、无水乙醇;水溶液呈调酸性反应。
  • 用途二:本品医药上是尿酶竞争抑制剂,用于尿肾结石等病症治疗;牧业上用于提高饲料蛋白质转化率 。也用于制备其它药物。
  • 急性毒性:腹腔-小鼠 LD50:1300 毫克/公斤
  • 乙酰氧肟酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 xw010089 乙酰氧肟酸 5g 320元 2011/04/16 A0051 乙酰氧肟酸 Acetohydroxamic Acid 25G 1450元 2011/04/16 A0051 乙酰氧肟酸 Acetohydroxamic Acid 10G 734元
  • Hazard Note:Toxic
  • 灭火剂:干粉、泡沫、砂土、二氧化碳, 雾状水
  • 外观性质:白色结晶或结晶性粉末,几乎无臭;味微苦;遇光变色;易吸潮;易溶于水、无水乙醇;水溶液呈调酸性反应。熔点:86-90°C
  • Acros Organics:乙酰氧肟酸 Acetohydroxamic acid, 98+%(546-88-3)
  • MOL 文件:546-88-3.mol
  • TCI Shanghai:乙酰氧肟酸 Acetohydroxamic Acid,>;95.0%(T)(546-88-3)
  • MSDS 信息:Acetohydroxamic acid(546-88-3).msds
  • 可燃性危险特性:可燃; 加热分解释放有毒氮氧化物烟雾
  • 类别:有毒物品
  • Alfa Aesar:乙酰羟肟酸,98% Acetohydroxamic acid, 98%(546-88-3)
  • 敏感性:Hygroscopic

系列性分类


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