Phloroglucinol 间苯三酚(无结晶水)

CAS 108-73-6 MFCD00002286

化学结构图

108-73-6
SMILES: Oc1cc(O)cc(O)c1

化学属性

Mol. FormulaC6H6O3
Mol. Weight126.11
Melting Point215.0 to 220.0 deg-C
Density1.0
TSCAYes
Refractive indexn20/D 1.365
Stability对光敏感
Flash Point14 °C

别名和识别编码

Chemical NamePhloroglucinol
CAS Number108-73-6
Synonym 5-Oxyresorcinolphloroglucin sym-Trihydroxybenzene 1,3,5-Cyclohexanetrione 1 间苯三酚 ?hloroglucin 1,2,3-三羥苯 1,3,5-Benzoltriol 苯三酚 弗罗罗格鲁辛 TRIHYDROXYBENZENE Benzene, 1,3,5-trihydroxy- Floroglucin Benzene-s-triol Phloroglucin 1,3,5-Benzenetriol s-Trihydroxybenzene sym-Trihydroxybenzene 间苯三酚(无水） Floroglucinol 1,3,5-Trihydroxycyclohexatriene Benzene-1,3,5-triol 间苯三酚,二水 5-Hydroxyresorcinol benzene,trihydroxy Phloroglucinol
MDL NumberMFCD00002286
PubChem Substance ID87574491
Beilstein Registry Number6,1092
EC Number203-611-2
Reaxys-RN1341907
Merck Number7328
Chemical Name Translation间苯三酚(无结晶水)
Wiswesser Line NotationQR CQ EQ
LabNetwork Molecule IDLN00001389
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分类

  • Allium cepa (Onion), Allium sativum (Garlic), Building Blocks, Chemical Synthesis, Fucus vesiculosus, Hypericum perforatum (St John′s wort), Nutrition Research, Organic Building Blocks, Oxygen Compounds, Phytochemicals by Plant (Food/Spice/Herb), Polyols
  • {SNA} Allium cepa (Onion), Allium sativum (Garlic), Cell Biology, Fucus vesiculosus, Hypericum perforatum (St John's wort), Miscellaneous Plant Growth Regulators, Molecular Biology, Nutrition Research, Phytochemicals by Plant (Food/Spice/Herb), Plant Biotechnology, Plant Growth Regulators, Plant Tissue Culture
  • {SNA} Allium cepa (Onion), Alliu

产品应用

  • 检定锑、砷、铈、铬酸盐、铬、金、铁、汞、亚硝酸盐、锇、钯、锡、钒、香草素和木质素等。测定戊糖、醛类、木质素、盐酸、甲醇、水合氯醛、松节油、木质化细胞组织和胃液中的游离酸（盐酸）。骨标本的脱钙。

相关文献及参考

  • Short: II/25D
  • Merck:14,7328
  • Selective monobromination cannot be achieved conventionally. For bromination-debromination protocols for the preparation of the mono- and di-brominated derivatives, see: Can. J. Chem., 67, 335 (1989).
  • Mizuuchi, Y., et al.: Biol. Pharm. Bull., 31, 2205 (2008),
  • Reacts with mono- or dimethylamine in DMF-water, with displacement of one of the OH groups, to give 5-aminoresorcinols: Helv. Chim. Acta, 56, 510 (1973).
  • The electron-rich nucleus undergoes acylation with nitriles under mild Lewis acid catalysis, to give ketones (Houben-Hoesch reaction).

安全信息

WGK Germany2
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P302+P352+P332+P313+P362+P364
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P332+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
Hazard statements
  • H303 May be harmfully swallowed 吞食可能有害
  • H315 Causes skin irritation 会刺激皮肤
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H341 Suspected of causing genetic defects 怀疑导致遗传性缺陷
  • H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
RTECSSY1050000
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Signal word
Safety Statements
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S7 Keep container tightly closed 保存在严格密闭容器中；
  • S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S37 Wear suitable gloves 戴适当手套；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
Storage condition Dark Room Light Sensitive & Hygroscopic 充氩保存 密封避光保存。
Hazard Codes F,Xi Xn Xi
UN Number UN 1170 3/PG 2
Warnings 危化品目录(2015) 危险化学品 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4050 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 3,187,1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3180 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,740,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   THERAP Therapie.  (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
   France)  V.1-    1946-  Volume(issue)/page/year: 17,1349,1962

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3180 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4550 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 3,187,1969

TYPE OF TEST            : Gene conversion and mitotic recombination
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 3 gm/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 135,109,1984

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 3 gm/L
REFERENCE :
   CALEDQ Cancer Letters (Shannon, Ireland).  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1975- Volume(issue)/page/year:
   14,251,1981

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 5 mg/kg
SEX/DURATION            : female 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - ovaries, fallopian tubes
REFERENCE :
   ENDOAO Endocrinology (Baltimore).  (Williams & Wilkins Co., 428 E. Preston
   St., Baltimore, MD 21203) V.1-    1917-  Volume(issue)/page/year:
   57,466,1955

其他信息

  • Sigma Aldrich:108-73-6(sigmaaldrich)
  • 毒性分级:中毒
  • Alfa Aesar:无水间苯三酚,98% Phloroglucinol,
  • {Chemica
  • 用途五:检定锑、砷、铈、铬酸盐、铬、金、铁、汞、亚硝酸盐、锇、钯、锡、钒、香草素和木质素等。测定戊糖、醛类、木质素、盐酸、甲醇、水合氯醛、松节油、木质化细胞组织和胃液中的游离酸（盐酸）。骨标本的脱钙。用于ICP-AES、AAS、AFS、ICP-MS、离子色谱等。滴定分析用标准溶液。
  • 可燃性危险特性:明火可燃燃烧产生刺激
  • 外观:淡黄色至白色结晶或粉末。无水物熔点217-219℃,二水合物熔点117℃,对皮肤及眼有刺激性,遇光颜色逐渐变深,味微甜。能升华并部分分解。水中溶解度: 10 g/l (20 C) ，溶于丙酮、乙醇、乙醚和吡啶。有毒，半数致死量（大鼠，经口）4550mg/kg。有刺激性。商品也有含2分子结晶水。
  • 可燃性危险特性:明火可燃燃烧产生刺激烟雾
  • 类别:有毒物品
  • 图谱信息:间苯三酚(108-73-6)质谱(MS) 间苯三酚(108-73-6)红外图谱(IR2) 间苯三酚(108-73-6)核磁图( 1 HNMR) 间苯三酚(108-73-6)红外图谱(IR1) 间苯三酚(108-73-6)核磁图( 13 CNMR)
  • 用途一:检定锑、砷、铈、铬酸盐、铬、金、铁、汞、亚硝酸盐、锇、钯、锡、钒、香草素和木质素等，测定糠醛、戊糖、多缩戊糖、甲醇、水合氯醛、松节
  • 用途二:108-73-6（间苯三酚）是合成黄酮的中间体，还可用于染料催合剂、合成橡胶稳定剂、偶氮复合油墨等的原料。血管扩张药盐酸丁咯地尔 (buflomedil hydrochloride) 的中间体。
  • 用途三:间苯三酚（108-73-6）是一种重要的医药中间体和化学通用试剂。广
  • 急性毒性:口服-大鼠 LD50: 4000 毫克/公斤; 口服-小鼠LD50: 4550 毫克/公斤
  • 用途三:间苯三酚（108-73-6）是一种重要的医药中间体和化学通用试剂。广泛用于保健品的合成、织物及皮革的染料稳定剂和抗腐蚀剂、人工造雨替代碘化银、塑料胶
  • 用途四:检定锑、砷、铈、铬酸盐、铬、金、铁、汞、亚硝酸盐、锇、钯、锡、钒、香草素和木质素等。测定戊糖、醛类、木质素、盐酸、甲醇、水合氯醛、松节油、木质化细胞组织和胃液中的游离酸（盐酸）。骨标本的脱钙。
  • 方法一:2，4，6-三硝基苯甲酸用锡粒还原得到2，4，6-三氨基苯甲酸，其稀溶液加热回流20h，用盐酸酸化，冷却结晶，得间苯三酚。收率46-53%。
  • 对皮肤及眼有刺激性,遇光颜色逐渐变深,味微甜。能升华并部分分解。水中溶解度: 10 g/l (20 C) ，溶于丙酮、乙醇、乙醚和吡啶。有毒，半数致
  • 敏感性:Light Sensitive & Hygroscopic
  • 间苯三酚价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 P0249 无水1,3,5-苯三酚 Phloroglucinol Anhydrous 25G 196元 2014/06/02 P0249 无水1,3,5-苯三酚 Phloroglucinol Anhydrous 250G 1170元 2010/06/21 241760500 间苯三酚 Phloroglucinol 99+%, anhydrous 50 GR 766元
  • 对皮肤及眼有刺激性,遇光颜色逐渐变深,味微甜。能升华并部分分解。水中溶解度: 10 g/l (20 C) ，溶于丙酮、乙醇、乙醚和吡啶。有毒，半数致死量（大鼠，经口）4550mg/kg。有刺激性。商品也有含2分子结晶水。
  • TCI Shanghai:无水1,3,5-苯三酚 Phloroglucinol Anhydrous,>;99.0%(LC)(108-73-6)
  • Acros Organics:无水间苯三酚 Phloroglucinol, anhydrous, 99+%(108-73-6)

系列性分类

  1. Life Science 生命科学
  2. Nutrition Research 营养研究
  3. Phytochemicals by Plant (Food/Spice/Herb) - Nutrition Research
  4. Allium sativum (Garlic) - Phytochemicals by Plant (Food/Spice/Herb)
  1. Life Science 生命科学
  2. Hematology and Histology 血液学和组织学
  3. Stains and Dyes - Hematology and Histology
  4. Stains & Dyes, A to Z - Stains and Dyes
  5. P - Stains & Dyes, A to Z
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Oxygen Compounds 氧化合物
  5. Phenols 酚类
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Oxygen Compounds 氧化合物
  5. Protected Alcohols/Phenols - Oxygen Compounds
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Oxygen Compounds 氧化合物
  5. Polyols - Oxygen Compounds
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Oxygen Compounds 氧化合物
  5. Phenols
  1. Life Science 生命科学
  2. Biochemistry / Glyco-Chemistry
  3. Plant Growth Regulators
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Molecular Biology
  4. Plant Growth Regulators
  5. Cytokinins
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Plant Biotechnology
  4. Plant Tissue Culture
  5. Plant Growth Regulators
  6. Cytokinins

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