Ethyl 4-hydroxybenzoate 尼泊金乙酯

CAS N/A MFCD00002353

化学结构图

N/A
SMILES:

化学属性

Mol. FormulaC9H10O3
Mol. Weight166.18
Boiling Point178°C/11mmHg(lit.)
Melting Point115.0 to 118.0 deg-C
Density1.168
TSCAYes
Stability对光敏感

别名和识别编码

Chemical NameEthyl 4-hydroxybenzoate
CAS Number120-47-8
Synonym p-Hydroxy benzoic acid ethyl ester Äthyl-p-hydroxybenzoat Ethyl p-oxybenzoate Mekkings E 4-Hydroxybenzoesäure-ethylester Ethyl Butex Ethyl-4-hydroxybenzoat Ester etylowykwasu p-hydroksybenzoesowego p-Carbethoxyphenol Nipagin® A 4-羟基苯甲酸乙酯, 99% 尼泊金乙酯 Aseptin A Solbrol A p-Hydroxybenzoic acid ethyl ester 4-Carbethoxyphenol Ethyl-p-hydroxybenzoat 4-hydroxy-benzoic acid ethyl ester Aseptine A p-Hydroxybenzoic ethyl ester p-Oxybenzoesaeureaethylester Benzoic acid, p-hydroxy-, ethyl ester Nipagina A Ethyl 4-hydroxybenzoate E 214 Ethyl-4-hydroxybenzoate Ethylester der p-Hydroxybenzoesäure Benzoic acid, 4-hydroxy-, ethyl ester Nipazin A Easeptol Napagin A PHB-Ester Ethylester kyseliny p-hydroxybenzoove 对羟基苯甲酸乙酯 尼泊金A 4-(Ethoxycarbonyl)phenol Mycocten Bonomold OE p-Carbethoxyphenol 4-hydroxybenzoic Acid Ethyl Ester Ethyl parasept Ethyl p-hydroxybenzoate Ethyl para 4-Hydroxybenzoesäureethylester Nipagin A Aseptoform E p-Hydroxybenzoic acid ethyl ester p-Hydroxybenzoic acid, ethyl ester Tegosept E Ethyl p-hydroxybenzoate 对羟基苯甲酸乙酯 尼泊金乙酯 p-Hydroxybenzoate ethyl ester 4-Hydroxybenzoic acid ethyl ester 4-carboethoxyphenol Ethyl-p-oxybenzoat
Beilstein Registry Number10,159
EC Number204-399-4
MDL NumberMFCD00002353
Reaxys-RN1101972
PubChem Substance ID87570640
Merck Number3837
Chemical Name Translation尼泊金乙酯
Wiswesser Line NotationQR DVO2
LabNetwork Molecule IDLN00193451
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分类

  • {SNA} A-F, All Alphabetically Sorted, Analytical Standards, Analytical/Chromatography, Antioxidants & Preservatives,
  • {SNA} Bu
  • {SNA} A-F,
  • {SNA} A-F, Analytical Standards, Analytical/Chromatography, Antioxidants & Preservatives, Chemical Class, Chromatography, E numbers (Food Additives), E200–E299 (preservatives), E214, Food & Beverage Standards, Pharmaceutical Secondary Standards, Pharmaceutical Standards, Phenol, Phenols, Preservatives, Standards for Personal Care and Cosmetic Products, Trigger for Food Allergies & Intolerances, 化合物分类, 按字母排序, 香精香料
  • {SNA} Building Blocks,

产品应用

  • 防腐剂(食品、药品)。抑菌剂。防霉剂。有机分析测定羰基和卤化物。
  • 该品对霉菌、酵母与细菌有广泛的抗菌作用，对霉菌与酵母的作用较强，但对细菌特别是对革兰氏阴性杆菌及乳酸菌的作用较差。是食品和医药的高效防腐杀菌剂。
  • 校准仪器和装置；评价方法；工作标准；质量保证/质量控制；其他。

相关文献及参考

  • Gilliland, D., et al.: J. Appl. Bacteriol., 72, 258
  • Merck: 14,3837
  • Short: III/35E
  • Short: IV/16
  • Short: IV/18B
  • Merck: 14,3837 Beilstein: 10,IV,367

安全信息

GHS Symbol
WGK Germany1
Signal word
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
RTECSDH2190000
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P352+P333+P313+P362+P364
  • P305+P351+P338+P337+P313
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes Xi
Storage condition 在常温、避光下保存。 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BCTKAG Bromatologia i Chemia Toksykologiczna.  (Ars Polona, POB 1001, 00-068
   Warsaw 1, Poland) V.4-    1971-  Volume(issue)/page/year: 14,301,1981

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 520 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DRSTAT Drug Standards.  (Washington, DC)  V.19-28, 1951-60.  For publisher
   information, see JPMSAE.  Volume(issue)/page/year: 20,89,1952

TYPE OF TEST

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FAONAU FAO Nutrition Meetings Report Series.  (Rome, Italy)  No.?-57,
   1948-77.  Discontinued.  Volume(issue)/page/year: 53A,81,1974

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FAONAU FAO Nutrition Meetings Report Series.  (Rome, Italy)  No.?-57,
   1948-77.  Discontinued.  Volume(issue)/page/year: 53A,81,1974

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Fibroblast
DOSE/DURATION           : 250 mg/L
REFERENCE :
   ESKHA5 Eisei Shikenjo Hokoku.  Bulletin of the Institute of Hygienic
   Sciences.  (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu,
   Setagaya-ku, Tokyo 158, Japan)  V.1-    1886-  Volume(issue)/page/year:
   (96),55,1978

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 440 mg/L
REFERENCE :
   GMCRDC Gann Monograph on Cancer Research.  (Plenum Pub. Corp., 233 Spring
   St., New York, NY 10013) No. 11-    1971-  Volume(issue)/page/year:
   27,95,1981

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 10 mmol/L
REFERENCE :
   ZBPIA9 Zentralblatt fuer Bakteriologie, Parasitenkunde,
   Infektionskrankheiten und Hygiene, Abteilung II. Naturwissenschaftliche:
   Allgemeine, Landwirtschaftliche und Technische Mikrobiologie. (Jena, Ger.
   Dem. Rep.)  V.107-132, 1952-77.  Volume(issue)/page/year: 112,226,1959

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 45600 mg/kg
SEX/DURATION            : female 8-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - other developmental
   abnormalities
REFERENCE :
   AOGLAR Acta Obstetrica et Gynaecologica Japonica, English Edition.  (Tokyo,
   Japan)  V.16-23, 1969-76. For publisher information, see NISFAY.
   Volume(issue)/page/year: 22,94,1975

其他信息

  • 无气味。易溶于乙醇、乙醚和丙酮，微溶于水、氯仿、二硫化碳和石油醚。有轻微特殊香气，味微苦，灼麻。半数致死量(小鼠，腹腔)522mg/kg。有刺激性。
  • 无气味。易溶于乙醇、乙醚和丙酮，微溶于水、氯仿、二硫化碳和石油醚。有轻微特殊香气，味微苦，灼麻。半数致死量(小鼠，腹腔)520mg/kg。有刺激性。
  • 无气味。易溶于乙醇、乙醚和丙酮，微溶于水、氯仿、二硫化碳和石油醚。有轻微特殊香气，味微苦，灼麻。半数致死量(小鼠，腹腔)521mg/kg。有刺激性。

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Esters - Carbonyl Compounds
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Esters - Carbonyl Compounds
  6. C8 to C9 - Esters
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Esters - Carbonyl Compounds
  6. C8 to C9 - Esters
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Food & Beverage Standards - Chromatography
  5. E numbers (Food Additives) - Food & Beverage Standards
  6. E200–E299 (preservatives) - E numbers (Food Additives)
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Esters
  6. C6 to C7