Sodium chloroacetate 氯乙酸钠

CAS 3926-62-3 MFCD00002684

化学结构图

3926-62-3
SMILES: O=C([O-])CCl.[Na+]

化学属性

Mol. FormulaC2H2ClNaO2
Mol. Weight116.48
Density1.399
Melting Point>210°C (dec.)
Flash Point-
TSCAYes
Solubility440 G/L (20 ºC)
Stability易吸潮
Boiling Point

别名和识别编码

Chemical NameSodium chloroacetate
Synonym Sodium a-Chloroacetate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
MDL Number-
CAS Number3926-62-3
EC Number223-498-3
Beilstein Registry Number3597157
Merck Number14,2112
PubChem Substance ID23665759
Chemical Name Translation氯乙酸钠
Wiswesser Line NotationQV1G &-NA-
LabNetwork Molecule IDLN00221588
InChIInChI=1S/C2H3ClO2.Na/c3-1-2(4)5;/h1H2,(H,4,5);/q;+1/p-1
Canonical SMILESO=C([O-])CCl.[Na+]
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分类

  • {SNA} Chemical Synthesis, Essential Chemicals, Inorganic Salts, Research Essentials, Salts, Sodium, Sodium Salts, Synthetic Reagents
  • {uni_hamburg} no charge; carboxylate; 2fragments; ionic
  • {SNA} Chemical Synthesis, Inorganic Salts, Sodium, Synthetic Reagents

产品应用

  • 有机合成。药用。除草剂。染料。

相关文献及参考

  • Merck: 14,2112
  • Short: III/20a
  • Short: IV/1a
  • A convenient method for the conversion of arylamines to the corresponding N,N-diacetic acids is by lithiation followed by reaction with sodium chloroacetate. For discussion and limitations, see: Sy
  • Short: EINECS
  • A convenient method for the conversion of arylamines to the corresponding N,N-diacetic acids is by lithiation followed by reaction with sodium chloroacetate. For discussion and limitations, see: Synthesis, 548 (1989).
  • Merck: 14,2112 Beilstein: 2,IV,478

安全信息

Signal word
GHS Symbol
WGK Germany2
Safety Statements
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S37 Wear suitable gloves 戴适当手套；
  • S22 Do not breathe dust 不要吸入粉尘；
Risk Statements
  • R25 Toxic if swallowed 吞咽有毒
  • R38 Irritating to skin 刺激皮肤
  • R36 Irritating to eyes 刺激眼睛
  • R50 Very toxic to aquatic organisms 对水生生物极毒
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P301+P310
  • P301+P312
  • P302+P352
  • P304+P340
  • P305+P351+P338
  • P308+P313
  • P309+P311
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医，如果你觉得不舒服
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P330 Rinse mouth. 漱口
  • P332+P313
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
RTECSAG1400000
Packing GroupIII
UN Number UN 2659 6.1/PG 3
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Hazard Codes T,N
Hazard Class6.1
Storage condition +4°C 4 4℃ Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
Warnings 危化品目录(2015) 危险化学品 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle contraction or spasticity
   Gastrointestinal - hypermotility, diarrhea
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   NVTMAF Nordisk Veterinaermedicin Danske Udgave.  (Copenhagen, Denmark)
   Volume(issue)/page/year: 13,271,1961

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 165 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 86,336,1946

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 95 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JIHTAB Journal of Industrial Hygiene and Toxicology.  (Cambridge, MA)
   V.18-31, 1936-49.  For publisher information, see AEHLAU.
   Volume(issue)/page/year: 23,78,1941

TYPE OF TEST

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 99 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JIHTAB Journal of Industrial Hygiene and Toxicology.  (Cambridge, MA)
   V.18-31, 1936-49.  For publisher information, see AEHLAU.
   Volume(issue)/

其他信息

  • 可燃性危险特性:可燃； 燃烧产生有毒氯化物和氧化钠烟雾
  • 氯乙酸钠价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 LA1237902 氯乙酸钠;氯醋酸钠 500g 220元 2011/08/23 80116326 氯乙酸钠;氯醋酸钠 100g 28.9元 2010/06/21 404410025 氯乙酸钠 Chloroacetic acid sodium salt 98% 2.5 KG 715元
  • 海关编码:29154000
  • 急性毒性:口服- 大鼠 LD50: 95 毫克/公斤;口服- 小鼠 LD50: 165 毫克/ 公斤
  • 无气味。溶于水(20℃ 85g/100ml)，微溶于甲醇，不溶于乙醚、苯、丙酮和四氯化碳。中等毒，半数致死量(大鼠，经口)95mg/kg。有刺激性。
  • 外观性质:白色粉末或结晶。
  • 用途五:有机合成。药用。除草剂。染料。
  • Acros Organics:氯乙酸钠 Chloroacetic acid sodium salt, 98%(3926-62-3)
  • 用途四:用于农药、医药等有机合成中。
  • 用途二:用于染料合成，还用作除草剂
  • MSDS 信息:一氯乙酸钠(3926-62-3).msds
  • Alfa Aesar:氯乙酸钠,98% Sodium chloroacetate, 98%(3926-62-3)
  • 敏感性:Hygroscopic
  • 用途三:用于合成染料、农药除草剂等
  • 上游原料:氯乙酸
  • 用途一:用于医药、化工等
  • 类别:腐蚀物品
  • MOL 文件:3926-62-3.mol
  • 方法一:由氯乙酸与氢氧化钠（或碳酸钠）反应而得。将氯乙酸溶解于无水乙醇中，冷却至20℃以下，慢慢加入氢氧化钠饱和溶液。反应完毕，冷却析出结晶。过滤，用乙醇洗涤，减压蒸馏，干燥而得成品。一般有机合成中只需要氯乙酸钠的水溶液。在这种情况下，将氯乙酸水溶液和碳酸钠于70℃反应，使反应pH为6.8-7，即得所需的氯乙酸钠溶液。
  • 灭火剂:砂土、雾状水
  • 下游产品:氰乙酸乙酯 --> 丙二酸二乙酯 --> 丙二酸 --> 硝基甲烷 --> 丙二酸二甲酯 --> 乙二胺四乙酸 --> 氰乙酸 --> 羧甲基纤维素 --> 亚氨基二乙酸 --> 稻瘟灵 --> 2,2-二溴-3-次氮基丙酰胺 --> 2,4-二氯苯氧乙酸 --> 依帕斯他 --> 次氮基三乙酸 --> 椰油酰胺基丙基甜菜碱 --> 2,4-二氯苯氧丁酸 --> XCG-CA-2椰油基羧甲基钠型醋酸盐 --> N-甲基亚氨二乙酸 --> 十二烷基二甲基甜菜碱 --> N,N-二甲基-N-十二烷基硫代亚丙基甜菜碱 --> 油酸肌氨酸钠 --> 甜菜碱 --> 脂肪醇聚氧乙烯醚羧酸盐 --> 氰乙酸正丁酯 --> N-十四烷基甘氨酸钠盐 --> N-月桂酰基-N'-羟乙基-羧丙基乙二胺丙酸内盐 --> 甘油醚羧酸盐 --> N-蓖麻油酰基-N-羟乙基-N-羧乙基乙二胺乙酸内盐 --> 2,4-滴丁酯 --> 二甲基烷基甜菜碱 --> 羧甲淀粉钠 --> 还原红 41 --> 椰油酰胺丙基甜菜碱 --> 椰油酰胺丙基甜菜碱
  • Sigma Aldrich:3926-62-3(sigmaaldrich)
  • 毒性分级:高毒
  • 爆炸物危险特性:对皮肤，角膜有腐蚀性
  • 储运特性:库房通风低温干燥; 与碱类、氧化剂分开存放。

系列性分类

  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Inorganic Salts - Synthetic Reagents
  4. Sodium - Inorganic Salts
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Esters - Carbonyl Compounds
  1. Analytical & Chromatography 分析化学与色谱
  2. Inorganic Salts
  3. Rubidium
  1. Functional Group 官能团索引
  2. carboxylic acid salt

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