Iodoacetic acid 碘乙酸

CAS 64-69-7 MFCD00002685

化学结构图

64-69-7
SMILES: O=C(O)CI

化学属性

Mol. FormulaICH2CO2H
Mol. Weight186
Melting Point78-83
TSCAYes
Boiling Point208° dec.
SolubilitySoluble in water (600 g/L) at 20 °C, and alcohol.
Density2.2694
Stability对光敏感
Flash Point208°C

别名和识别编码

Chemical NameIodoacetic acid
CAS Number64-69-7
PubChem Substance ID5240
EC Number200-590-1
Beilstein Registry Number1739079
MDL NumberMFCD00002685
Synonym 碘代醋酸 {uni_hamburg} MIA Aceticacid,iodo- IODOACETIC ACID FREE ACID APPROX 99%,*YE LLOW POWDER 醋酸碘 iodoacetate 碘代乙酸 IodoaceticAcid97% CH2ICOOH IODOACETIC ACID APPROX. 99% WHITE TO OFF IA 碘醋酸 iodoacetic acid RARECHEM AL BO 0101 碘乙酸 iodo-acetic acid IODOACETIC ACID Kyselina jodoctova VITAS-BB TBB000669 IODOACETICACID,REAGENT IodoaceticAcid>99% iodo-aceticaci 碘乙酸, 97+% monoiodoacetate IODOACETIC ACID R. G. iodoacetic MONOIODOACETIC ACID Monoiodoacetic acid kyselinajodoctova Acetic acid, iodo- IODOACETIC ACID MONO Iodoacetate Jodessigsäure Iodessigsäure Iodoacetic acid 2-Iodoacetic acid Monoiodoacetate
Merck Number14,5025
Chemical Name Translation碘乙酸
Wiswesser Line NotationQV1I
LabNetwork Molecule IDLN00195094
InChIInChI=1S/C2H3IO2/c3-1-2(4)5/h1H2,(H,4,5)
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分类

  • {SNA} Biochemicals and Reagents, D to K, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Glutamyltranspeptidase, gamma-, Glyceraldehyde-3-phosphate dehydrogenase, P to Q, Phospholipase C, phosphatidylinositol-specific
  • Biochemicals and Reagents, D to K, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Glutamyltranspeptidase, gamma
  • {SNA} D to K, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Glutamyltranspeptidase, gamma-, Glyceraldehyde-3-phosphate dehydrogenase, P to Q, Phospholipase C, phosphatidylinositol-specific, 生化试剂, 酶、抑制剂和底物
  • {SNA} Acids,

产品应用

  • 有机合成,酶的抑制剂,测定疏基。

相关文献及参考

  • Short: II/27B
  • Merck: 14,5025
  • Merck: 14,5025 Beilstein: 2,IV,534
  • Merck 14 ,5025
  • Short: III/20c

安全信息

GHS Symbol
WGK Germany1
Hazard statements
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H301 Toxic if swallowed 吞食有毒
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Hazard Codes 8 T,C T;C
RTECSAI3500000
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P310
  • P301+P330+P331
  • P305+P351+P338
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
Signal word Danger
Safety Statements
  • S1/2 None 上锁保管并避免儿童触及;
  • S22 Do not breathe dust 不要吸入粉尘;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
Packing GroupI
UN Number 2923
Risk Statements
  • R25 Toxic if swallowed 吞咽有毒
  • R35 Causes severe burns 会导致严重灼伤
Storage condition Light Sensitive 储存温度 -20℃ 储存温度2-8℃ 2-8°C
Hazard Class8
Warnings 危化品目录(2015)
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 480 mg/kg/14W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   GANNA2 Gann.  Japanese Journal of Cancer Research.  (Tokyo, Japan)  V.1-75,
   1907-84.  For publisher information, see JJCREP.  Volume(issue)/page/year:
   45,601,1954

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 5800 mg/kg/27W-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Skin and Appendages - tumors
   Tumorigenic - tumors at site of application
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   7,482,1953

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 480 mg/kg/8W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
   Tumorigenic - tumors at site of application
REFERENCE :
   AICCA6 Acta Unio Internationalis Contra Cancrum.  (Louvain, Belgium) V.1-20,
   1936-64.  For publisher information, see IJCNAW. Volume(issue)/page/year:
   11,699,1955

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 75 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RPTOAN Russian Pharmacology and Toxicology (English Translation).
   Translation of FATOAO.  (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey,
   UK)  V.30-    1967-  Volume(issue)/page/year: 41,113,1978

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 60 mg/kg
TOXIC EFFECTS :
   Behavioral - fluid intake
   Behavioral - rigidity (including catalepsy)
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   26,93,1973

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 60 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - rigidity (including catalepsy)
REFERENCE :
   JPHYA7 Journal of Physiology.  (Cambridge Univ. Press, 32 E. 57th St., New
   York, NY 10022) V.1-    1878-  Volume(issue)/page/year: 80,360,1934

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 45 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - other changes
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
   Nutritional and Gross Metabolic - other changes
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publish

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human HeLa cell
DOSE/DURATION           : 500 umol/L
REFERENCE :
   RAREAE Radiation Research.  (Academic Press, Inc., 1 E. First St., Duluth,
   MN 55802)  V.1-    1954-  Volume(issue)/page/year: 37,334,1969

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Ascites tumor
DOSE/DURATION           : 2143 umol/L
REFERENCE :
   JPMSAE Journal of Pharmaceutical Sciences.  (American Pharmaceutical Assoc.,
   2215 Constitution Ave., NW, Washington, DC 20037)  V.50-    1961-
   Volume(issue)/page/year: 67,1235,1978

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 5 mg/L
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 294,263,1981

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Fibroblast
DOSE/DURATION           : 100 ug/L
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 3,499,1982

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 40 mg/kg
SEX/DURATION            : female 8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   NCIMAV National Cancer Institute, Monograph.  (U.S. Government Printing
   Office, Supt. of Documents, Washington, DC 20402)  No.1-    1959-
   Volume(issue)/page/year: 2,41,1960

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 20 mg/kg
SEX/DURATION            : female 13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 7,177,1973

Restrict 危险品

其他信息

  • 用途一:用于有机合成、染料工业,也用于植物资源的研究
  • 能溶于水和醇,极微溶于醚
  • Alfa Aesar:碘乙酸,97+% Iodoacetic acid, 97+%(64-69-7)
  • Sigma Aldrich:64-69-7(sigmaaldrich)
  • 敏感性:Light Sensitive
  • MSDS 信息:碘乙酸(64-69-7).msds
  • MOL 文件:64-69-7.mol
  • 急性毒性:吸入- 大鼠 LCL0: 94毫克/立方米/30分; 腹腔- 大鼠 LD50: 75毫克/公斤
  • 碘乙酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 LA1241001 碘乙酸;碘代醋酸 25g 360元 2011/08/23 K0065201 碘乙酸(2-8℃) 10g 400元 2010/06/21 122280250 碘乙酸 Iodoacetic acid 97% 25 GR 636元
  • 储运特性:库房通风低温干燥; 与氧化剂、碱类分开存放。
  • 可燃性危险特性:可燃; 加热排放有毒碘化物烟雾
  • 外观性质:无色或白色结晶。
  • 图谱信息:碘乙酸(64-69-7)核磁图( 1 HNMR) 碘乙酸(64-69-7)红外图谱(IR1) 碘乙酸(64-69-7)红外图谱(IR2) 碘乙酸(64-69-7)核磁图( 13 CNMR) 碘乙酸(64-69-7)质谱(MS)
  • 海关编码:29159080
  • color:faintly yellow
  • 类别:腐蚀物品
  • F:8-9
  • 下游产品:氯诺昔康
  • 方法一:由氯乙酸与碘化钠反应而得。将氯乙酸、水(或丙酮)、碘化钠混合,在50℃反应1h。过滤,用冰冷至10℃析出结晶。过滤得粗品,用水重结晶得成品。
  • 灭火剂:砂土、泡沫、雾状水、二氧化碳
  • 毒性分级:高毒
  • 用途二:有机合成,酶的抑制剂,测定疏基。
  • 上游原料:乙酸 --> 碘 --> 氯乙酸 --> 醋酸铜
  • Iodoacetic acid is a reagent for the modification and alkylation of cysteine residues in proteins. It has also been used in glycopeptide synthesis.
  • Acros Organics:碘乙酸 Iodoacetic acid, 97%(64-69-7)

系列性分类