2-Iodoacetamide 2-碘乙酰胺

CAS 144-48-9 MFCD00008028

化学结构图

144-48-9
SMILES: NC(=O)CI

化学属性

Mol. FormulaC2H4INO
Mol. Weight184.96
Melting Point92-95°C
Density2.278
TSCAYes
Solubility略溶于水
Appearance crystalline 2-碘乙酰胺(144-48-9)为白色结晶。熔点95℃。溶于热水,易溶于乙醇。
Stability光及湿度敏感
Boiling Point297.1°C at 760 mmHg

别名和识别编码

Chemical Name2-Iodoacetamide
CAS Number144-48-9
PubChem Substance ID87571450
EC Number205-630-1
Beilstein Registry Number2(4)536
MDL NumberMFCD00008028
Synonym 2-Iodoacetamide {LY} 2-Iodoacetamide {} {LY} 2-Iodoacetamide {} {} {LY} 2-Iodoacetamide {} {} {} {LY} 2-Iodoacetamide {} {} {} {} {LY} 2-Iodoacetamide {} {} {} {} {} {LY} 2-Iodoacetamide {} {} {} {} {} {} {LY} 2-Iodoacetamide {} {} {} {} {} {} {} {LY} 2-Iodoacetamide {} {} {} {} {} {} {} {} {LY} 2-Iodoacetamide {} {} {} {} {} {} {} {} {} {LY} 2-Iodoacetamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Iodoacetamide {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Iodoacetamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Iodoacetamide {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Iodoacetamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Iodoacetamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Iodoacetamide
Alfabeta NameIODOACETAMIDE 2-
Reaxys-RN1739080
Chemical Name Translation2-碘乙酰胺
Wiswesser Line NotationZV1I
LabNetwork Molecule IDLN00007307
InChIInChI=1S/C2H4INO/c3-1-2(4)5/h1H2,(H2,4,5)
Canonical SMILESO=C(N)CI
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分类

  • {SNA} Cell Lysis and Protein Extraction Reagents, Chemical Modification Reagents, Protein Modification, Reagents for cysteine modification, Specific Amino Acid Modification, 分子生物学, 天然蛋白质样品制备, 蛋白质组学, 蛋白质结构分析
  • {SNA} Cell Lysis and Protein Extraction Reagents, Chemical Modification Reagents, Native Protein Sample P

产品应用

  • 在蛋白组学中组氨酸和半胱氨酸的烷基化试剂,用于多肽测序以及酶抑制剂。也用于有机合成。

相关文献及参考

  • 1. Gomi, T., and Fujioka, M., Inactivation of rat liver S-adenosylhomocysteinase by iodoacetamide Biochemistry 21 , 4171-4176, (1982) 摘要
  • 2. Takahashi, K., The structure and function of ribonuclease T1. XXI. Modification of histidine residues in ribonuclease T1 with iodoacetamide J. Biochem. 80 , 1267-1275, (1976) 摘要
  • Snider, J., et al., Formation of a Distinctive Complex between the Inducible Bacterial Lysine Decarboxylase and a Novel AAA+ ATPase J. Biol. Chem. 281 , 1532-46, (2006) 摘要
  • Beil. 2 ,IV,536
  • Aldrich MSDS 1 , 1089:C / Corp MSDS 1 (1), 1990:B / FT-IR 2 (1), 1259:C / FT-IR 1 (1), 751:B / IR-Spectra (2), 389:B / IR-Spectra (3), 439:C / NMR-Reference 2 (1), 632:C / RegBook 1 (1), 879:D / Sax 6 , 1617 / Sigma FT-IR 1 (2), 656:D / Structure Index 1 , 134:B:5
  • Short: II/25B Title: Structure Data Of Free Polyatomic Molecules: Molecules containing One or Two Carbon Atoms Author: Graner, G.; Hirota, E.; Iijima, T.; Kuchitsu, K.; Ramsay, D.A.; Vogt, J.; Vogt, N. Editor: Kuchitsu, K. Source: Landolt-Börnstein, New Series Volume: II/25B Year: 1999 Keyword: Free Polyatomic Molecules; Carbon Atoms; Molecules ISBN: 3-540-63645-5 ISBN: 978-3-540-63645-8 Internet Resource: DOI:10.1007/b68834 RefComment: IX, 512 pages. Hardcover Abstract: Volume II/25 is a supplemented and revised edition of the preceding volumes II/7, II/15, II/21 and II/23 containing up to date information on inorganic and organic polyatomic molecules. All experimental methods for the determination of quantitative structural data of free molecules have been considered: microwave, infrared, Raman, electronic and photoelectron spectroscopy as well as electron diffraction. The data obtained by these methods have been critically evaluated and compiled. They are presented separately for each molecule, together with a schematic figure of the structure

安全信息

GHS Symbol
WGK Germany3
Hazard Codes T
Hazard statements
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难
  • H301 Toxic if swallowed 吞食有毒
  • H413 Maycauselonglastingharmfuleffectstoaquaticlife 可能对水生生物造成长期持续有害影响。
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
RTECSAC4200000
Precautionary statements
  • P301+P310
  • P342+P311
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P310+P330
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P305+P351+P338
  • P332+P313
  • P302+P352+P332+P313+P362+P364
  • P405 Store locked up. 上锁保管。
  • P305+P351+P338+P337+P313
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
Signal word
Safety Statements
Risk Statements
  • R25 Toxic if swallowed 吞咽有毒
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
Packing GroupIII
UN Number UN 2811 6.1/PG 3 2811
Storage condition 2-8°C, sealed storage, away from moisture and light {LY} 2-8°C, sealed storage, away from moisture and light Light Sensitive {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture and light {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture and li
Warnings IRRITANT
Hazard Class6.1
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1480 mg/kg/20W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
   Tumorigenic - tumors at site of application
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   7,482,1953

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 74 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   47,179,1981

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: AD277-689

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 56 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#02060

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 10 umol/L
REFERENCE :
   STBIBN Studia Biophysica.  (Akademie-Verlag GmbH, Postfach 1233, Berlin
   DDR-1086, Ger. Dem. Rep.) V.1-    1966-  Volume(issue)/page/year: 50,97,1975

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 20 ppm
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 24,365,1974

其他信息

  • F:8-10-21
  • 方法一:由氯乙酰胺与碘化钠反应而得。将氯乙酰胺、无水丙酮、无水碘化钠在浴上回流15h。冷至室温,滤出氯化钠,回收丙酮,稍冷后倒入硫酸氢钠的冰水中,然后用硫酸钠饱和溶液中和至pH6。冷却结晶,过滤得粗品。粗品用水重结晶,即得成品。
  • 用途一:用于有机合成
  • Acros Organics:碘乙酰胺 Iodoacetamide, 98%(144-48-9)
  • 用途二:在蛋白组学中组氨酸和半胱氨酸的烷基化试剂,用于多肽测序以及酶抑制剂。也用于有机合成。
  • 海关编码:29241900
  • MSDS 信息:2-Iodoacetamide(144-48-9).msds
  • TCI Shanghai:2-碘乙酰胺 2-Iodoacetamide,>;98.0%(T)(144-48-9)
  • MOL 文件:144-48-9.mol
  • Sigma Aldrich:144-48-9(sigmaaldrich)
  • 溶于热水,易溶于乙醇。
  • 图谱信息:2-碘乙酰胺(144-48-9)核磁图( 13 CNMR) 2-碘乙酰胺(144-48-9)红外图谱(IR2) 2-碘乙酰胺(144-48-9)核磁图( 1 HNMR) 2-碘乙酰胺(144-48-9)红外图谱(IR1) 2-碘乙酰胺(144-48-9)质谱(MS)
  • 2-碘乙酰胺价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 LA1471502 碘代乙酰胺 25g 719元 2011/08/23 K5767001 碘代乙酰胺(+4℃) 25g 1650元 2011/04/16 I0741 2-碘乙酰胺[用于生化研究] 2-Iodoacetamide [for Biochemical Research] 5G 509元
  • 上游原料:丙酮 --> 碘化钠 --> 氯乙酰胺 --> 无水丙酮
  • TSCA:T
  • Alfa Aesar:2-碘乙酰胺,98%,stab.withca5-8%water 2-Iodoacetamide, 98%, stab. with ca 5-8% water(144-48-9)
  • 敏感性:Light Sensitive

系列性分类