2-Butyne-1,4-diol 1,4-丁炔二醇

CAS 110-65-6 MFCD00002915

化学结构图

110-65-6
SMILES: OCC#CCO

化学属性

Mol. FormulaC4H6O2
Mol. Weight86
Boiling Point238
Melting Point54-58
Flash Point152°(305°F)
TSCAYes
Vapor Pressure<;0.1 mmHg ( 55 °C)
Refractive index1.480
Density1.2
Solubility易溶于水,易溶于甲醇、乙醇,不溶于乙醚、苯、氯仿。
Stability对湿度敏感

别名和识别编码

Chemical Name2-Butyne-1,4-diol
CAS Number110-65-6
PubChem Substance ID87563749
EC Number203-788-6
Beilstein Registry Number1071237
MDL NumberMFCD00002915
Reaxys-RN1071237
Synonym 1,4-Dihydroxy-2-butyne, 1,2-Dihydroxydimethylacetylene 2-Butin-1,4-diol 2-丁炔-1,4-二醇 Bis(hydroxymethyl)acetylene but-2-yne-1,4-diol
Chemical Name Translation1,4-丁炔二醇
Wiswesser Line NotationQ2UU2Q
LabNetwork Molecule IDLN00193774
InChIInChI=1S/C4H6O2/c5-3-1-2-4-6/h5-6H,3-4H2
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分类

  • Alkynes, Building Blocks, Chemical Synthesis, Internal, Organic Building Blocks
  • {uni_hamburg} no charge; alcohol; 1fragment
  • {SNA} Alkynes, Building Blocks, Chemical Synthesis, Internal, Organic Building Blocks

产品应用

  • 丁二烯合成的中间体,腐蚀抑制剂,电镀光亮剂,聚合催化剂,脱叶剂,氯烃稳定剂。

相关文献及参考

  • Beilstein:1(1)261
  • Short: II/27B
  • Undergoes an interesting trans-addition reaction with Grignard reagents: Chem. Lett., 765 (1984):
  • Short: III/38B

安全信息

GHS Symbol
WGK Germany2
Hazard statements
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H301+H331
  • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
  • H312 Harmful in contact with skin 皮肤接触有害
  • H301+H311+H331
  • H331 Toxic if inhaled 吸入中毒
  • H301 Toxic if swallowed 吞食有毒
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Hazard Codes 6.1 T
RTECSES0525000
Precautionary statements
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P310
  • P301+P330+P331+P310
  • P303+P361+P353
  • P303+P361+P353+P310+P363
  • P304+P340+P310
  • P304+P340+P311
  • P305+P351+P338
  • P305+P351+P338+P310
  • P308+P311
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P403+P233
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
UN Number 2716
Storage condition 0-10 密闭贮存. 0-10°C 储存温度2-8℃,充氩保存
Safety Statements
  • S25 Avoid contact with eyes 避免眼睛接触;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S46 If swallowed, seek medical advice immediately and show this container or label 食入时,立即求医并出示容器/标签;
Risk Statements
  • R21 Harmful in contact with skin 与皮肤接触有害
  • R23/25 Toxic by inhalation and if swallowed 吸入及吞食都有毒
  • R34 Causes burns 会导致灼伤
  • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
  • R48/22
Packing GroupIII
Hazard Class6.1
Warnings 危化品目录(2015)
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - respiratory stimulation
   Blood - other changes
REFERENCE :
   HYSAAV Hygiene and Sanitation (USSR).  English translation of GISAAA.
   (Springfield, VA)  1964-

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 105 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - respiratory stimulation
   Blood - other changes
REFERENCE :
   HYSAAV Hygiene and Sanitation (USSR).  English translation of GISAAA.
   (Springfield, VA)  1964-71. Discontinued.  Volume(issue)/page/year:
   33(1-3),41,1968

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 105 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - respiratory stimulation
   Blood - other changes
REFERENCE :
   HYSAAV Hygiene and Sanitation (USSR).  English translation of GISAAA.
   (Springfield, VA)  1964-71. Discontinued.  Volume(issue)/page/year:
   33(1-3),41,1968

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 52435 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPPMAB Journal of Pharmacy and Pharmacology.  (Pharmaceutical Soc. of Great
   Britain, 1 Lambeth High St., London SEI 7JN, UK)  V.1-    1949-
   Volume(issue)/page/year: 26,597,1974

Restrict 危险品

其他信息

  • 易吸湿。化学性质活泼。易溶于水、酸性溶液、醇和丙酮,不溶于苯和醚。中等毒,半数致死量(大鼠,经口)104mg/kg。能刺激皮肤。固体丁炔二醇在空气中易潮解,有毒,具有二元伯醇的化学性质,还可进行加成反应。

系列性分类