N-Methylformamide N-甲基甲酰胺

CAS 123-39-7 MFCD00003280

化学结构图

123-39-7
SMILES: CNC=O

化学属性

Mol. FormulaC2H5NO
Mol. Weight59.07
Density1.011
Refractive index1.4310 to 1.4340
Boiling Point199°C at 760 mmHg
Melting Point-3.2°C
Flash Point81.5±3.7 °C
TSCAYes
SolubilityMISCIBLE
pH:A

别名和识别编码

Chemical NameN-Methylformamide
Synonym N-Methylformamide {LY} N-Methylformamide {} {LY} N-Methylformamide {} {} {LY} N-Methylformamide {} {} {} {LY} N-Methylformamide {} {} {} {} {LY} N-Methylformamide {} {} {} {} {} {LY} N-Methylformamide {} {} {} {} {} {} {LY} N-Methylformamide {} {} {} {} {} {} {} {LY} N-Methylformamide {} {} {} {} {} {} {} {} {LY} N-Methylformamide {} {} {} {} {} {} {} {} {} {LY} N-Methylformamide {} {} {} {} {} {} {} {} {} {} {LY} N-Methylformamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} N-Methylformamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} N-Methylformamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} N-Methylformamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} N-Methylformamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} N-Methylformamide {} {} {} {} {} {} {} {} {} {} {
CAS Number123-39-7
EC Number204-624-6
Beilstein Registry Number4,58
MDL NumberMFCD00003280
PubChem Substance ID31254
Merck Number6076
Reaxys-RN1098352
Chemical Name TranslationN-甲基甲酰胺
Wiswesser Line NotationVHM1
LabNetwork Molecule IDLN00224732
InChIInChI=1S/C2H5NO/c1-3-2-4/h2H,1H3,(H,3,4)
Canonical SMILESO=CNC
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分类

  • {SNA} Amides, Building Blocks, C2 to C7, Carbonyl Compounds, Chemical Reagents, Chemical Synthesis, Development Quantities for Research, Organic Building Blocks
  • {SNA} Amides, Building Blocks, C2 to C7, Carbonyl Compounds, Chemical Synthesis, Organic Building Blocks
  • {Chemicalbook} 农药中间体: 杀螨剂中间体
  • {uni_hamburg} no charge; 1fragment
  • {SNA} Chemical Reagents, Amides, Building Blocks, C2 to C7, Carbonyl Compounds, Chemical Synthesis, Development Quantities for Research, Organic Building Blocks

产品应用

  • 是重要的有机化工原料和中间体,是一种性能较好的有机溶剂。用于合成高效低毒的单甲咪,双甲咪等。用作有机合成的反应溶剂和精制溶剂。还广泛用于医药、染料、香料及电解、电镀工业等。

相关文献及参考

  • Short: II/24C
  • Merck: 14,6076
  • Reagent for replacement of an activated chlorine in an aromatic or heteroaromatic ring by the methylamino group: Synthesis, 39 (1980).
  • Short: II/14a
  • Merck: 14,6076 Beilstein:4,58
  • Short: II/24B
  • Precursor of methyl isocyanide (highly toxic!), by dehydration with tosyl chloride in pyridine: Org. Synth. Coll., 5, 772 (1973).

安全信息

Signal word
GHS Symbol
WGK Germany1
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S53 Avoid exposure - obtain special instructions before use 避免接触,使用前获得特别指示说明;
Risk Statements
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P308+P313
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
  • P405 Store locked up. 上锁保管。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338+P337+P313
  • P308+P311
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
  • P302+P352+P312+P362+P364
Hazard statements
  • H303 May be harmfully swallowed 吞食可能有害
  • H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
  • H312 Harmful in contact with skin 皮肤接触有害
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSLQ3000000
Hazard Codes T
Packing GroupII
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2400 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - corneal damage
   Behavioral - somnolence (general depressed activity)
   Musculoskeletal - other changes
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 57(2),30,1992

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JRPFA4 Journal of Reproduction and Fertility.  (Biochemical Soc. Book Depot,
   POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK)  V.1-    1960-
   Volu

{hazar

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 802 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCISP* National Cancer Institute Screening Program Data Summary,
   Developmental Therapeutics Program. (Bethesda, MD 20205)
   Volume(issue)/page/year: JAN1986

TYPE OF TEST

TYPE OF TEST            :

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1580 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXCYAC Toxicology.  (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
   Limerick, Ireland) V.1-    1973-  Volume(issue)/page/year: 34,173,1985

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 70 mg/kg
SEX/DURATION            : female 11 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
   Reproductive - Specific Developmental Abnormalities - other developmental
   abnormalities
REFERENCE :
   DABBBA Dissertation Abstracts International, B: The Sciences and
   Engineering.  (University Microfilms International, 300 N. Zeeb Rd., Ann
   Arbor, MI 48106)  V.30-    1969-  Volume(issue)/page/year: 40,549,1979

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 650 mg/kg
SEX/DURATION            : female 6-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 30,1557,1980

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 650 mg/kg
SEX/DURATION            : female 6-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted

Storage condition -20°C, stored under nitrogen {LY} -20°C, stored under nitrogen Store at room temperature {} {LY} -20°C, stored under nitrogen {} {} {LY} -20°C, stored under nitrogen {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {}

其他信息

  • 上游原料:甲酸 --> 一甲胺 --> 甲酸乙酯 --> 一氧化碳 --> 甲酸甲酯
  • {Chem
  • 方法二:1.甲胺法由甲胺与一氧化碳反应制得。2.甲酸甲酯法由甲酸甲酯与甲胺反应而得。3.由甲酸乙酯和甲胺反应而得。将甲酸乙酯加入反应器中,在冷却下加入甲胺水溶液,于40℃回流反应。然后放置3d,减压回收乙醇得到粗品。再经减压蒸馏而得成品。
  • 毒性分级:中毒
  • 灭火剂:泡沫、二氧化碳、雾状水、砂土
  • 用途三:用作有机合成原料,用于农药杀虫药剂、医药、合成革、人造革等的合成;以及用作化纤纺织溶剂等。
  • 急性毒性:口服- 大鼠 LD50: 4000 毫克/ 公斤; 口服- 小鼠 LD50: 2600 毫克/ 公斤
  • 刺激数据:眼睛- 兔子 100 毫克
  • 下游产品:双甲眯 --> 2-甲基氨基吡啶
  • MOL 文件:123-39-7.mol
  • Alfa Aesar:N-甲基甲酰胺,99% N-Methylformamide, 99%(123-39-7)
  • Sigma Aldrich
  • 有氨味。可与苯互溶,溶于水、醇和丙酮,不溶于醚。
  • 用途四:是重要的有机化工原料和中间体,是一种性能较好的有机溶剂。用于合成高效低毒的单甲咪,双甲咪等。用作有机合成的反应溶剂和精制溶剂。还广泛用于医药、染料、香料及电解、电镀工业等。
  • 类别:易燃液体
  • 图谱信息:N-甲基甲酰胺(123-39-7)核磁图( 13 CNMR) N-甲基甲酰胺(123-39-7)红外图谱(IR1) N-甲基甲酰胺(123-39-7)核磁图( 1 HNMR) N-甲基甲酰胺(123-39-7)质谱(MS)
  • 可燃性危险特性:遇明火、高温、强氧化剂可燃;燃烧排放有毒氮氧化物烟雾
  • 方法一:N-甲基甲酰胺主要有以下三种合成工艺。 (1)甲胺法 由甲胺与一氧化碳作用而得。CO+CH 3 NH 2 →HCONHCH 3 将一甲胺69.62%(质量分数)、甲醇29.87%(质量分数)和甲醇钠0.5%(质量分数)(对于一甲胺为0.72%)的混合物向反应器供给87.05kg/h,同时供给含量为99.5%的一氧化碳56.5kg/h,反应温度90℃,压力2.53MPa。每小时取出含一甲胺80.5%(质量分数)的混合物140.75kg,即N-甲基甲酰胺生成量为每小时113.4kg,1L反应器的生产能力为每小时1.89kg N-甲基甲酰胺。 (2)甲酸甲酯法 由甲酸甲酯与甲胺反应而得。 CH 3 NH 2 +HCOOCH 3 →HCONHCH 3 +CH 3 OH 产物经初馏、精馏而得成品,总收率达90%;产品含量95%~99.5%以上。 (3)甲酸乙酯法 由甲酸乙酯和甲胺作用而得。 HCOOC 2 H 5 +CH 3 NH 2 →HCONHCH 3 +C 2 H 5 OH 先将甲酸乙酯加入反应罐中,然后在冷却下加入甲胺水溶液[甲酸乙酯和甲胺水溶液按1∶1.2(mol)配料],于40℃回流搅拌,然后放置3d,减压回收乙醇,粗品经减压蒸馏而得成品。
  • 储运特性:包装完整、轻装轻放; 库房通风、远离明火、高温、与氧化剂、酸分开
  • TCI Shanghai:N-甲基甲酰胺 N-Methylformamide,>;99.0%(GC)(123-39-7)
  • 用途二:N-甲基甲酰胺是一种重要的有机合成原料,用于农药杀虫杀螨剂单甲脒、双甲脒的合成,也用于生产医药、合成革、人造革以及用作化纤纺织溶剂等。
  • Acros Organics:N-甲基甲酰胺 N-Methylformamide, 99+%(123-39-7)
  • N-甲基甲酰胺价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 xw010203 N-甲基甲酰胺;N-甲酰基甲胺 100g 85元 2011/04/16 F0059 N-甲基甲酰胺 N-Methylformamide 25G 175元 2011/04/16 F0059 N-甲基甲酰胺 N-Methylformamide 500G 550元

系列性分类


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