N-Methylacetamide N-甲基乙酰胺

CAS 79-16-3 MFCD00008683

化学结构图

79-16-3
SMILES: CNC(C)=O

化学属性

Mol. FormulaC3H7NO
Mol. Weight73.09
Density0.957
Refractive indexn20/D 1.433(lit.)
Flash Point116°(240°F)
TSCAYes
Boiling Point204-206 °C at 760 mmHg
Melting Point26-28 °C
Solubility可溶
Stability对光敏感
Appearance 白色针状结晶。熔点30.55℃（28℃），沸点206℃，140.5℃（12kPa），相对密度0.9571（25/4℃），折光率1.4301，闪点108℃。溶于水、乙醇、苯、醚、氯仿，不溶于石油醚。

别名和识别编码

Chemical NameN-Methylacetamide
Synonym N-Methylacetamide {LY} N-Methylacetamide {} {LY} N-Methylacetamide {} {} {LY} N-Methylacetamide {} {} {} {LY} N-Methylacetamide {} {} {} {} {LY} N-Methylacetamide {} {} {} {} {} {LY} N-Methylacetamide {} {} {} {} {} {} {LY} N-Methylacetamide {} {} {} {} {} {} {} {LY} N-Methylacetamide {} {} {} {} {} {} {} {} {LY} N-Methylacetamide {} {} {} {} {} {} {} {} {} {LY} N-Methylacetamide {} {} {} {} {} {} {} {} {} {} {LY} N-Methylacetamide {} {} {} {} {} {} {} {} {} {} {} {LY} N-Methylacetamide {} {} {} {} {} {} {} {} {} {} {} {} {LY} N-Methylacetamide {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} N-Methylacetamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} N-Methylacetamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} N-Methylacetamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} N-Methylacetamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} N-Methylacetamide {} {} {} {} {} {} {} {} {} {}
CAS Number79-16-3
EC Number201-182-6
Beilstein Registry Number4,58
MDL NumberMFCD00008683
PubChem Substance ID87572237
Reaxys-RN1071255
Chemical Name TranslationN-甲基乙酰胺
Wiswesser Line Notation1VM1
LabNetwork Molecule IDLN00221264
InChIInChI=1S/C3H7NO/c1-3(5)4-2/h1-2H3,(H,4,5)
Canonical SMILESCNC(C)=O
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分类

  • {uni_hamburg} no charge; amide; 1fragment
  • {SNA} Building Blocks, Chemical Synthesis, Nitrogen Compounds, Organic Building Blocks, Protected Amines

产品应用

  • 因它具有溶解其它有机物的优良机物性能的优良性能，所以在有机合成上常用作溶剂。N-甲基乙酰胺对于某些化学反应有催化作用，在非极性溶剂中又是一个脱酸剂。

相关文献及参考

  • Beilstein:4,58
  • Short: II/25C
  • Short: II/27B

安全信息

Signal word
GHS Symbol
WGK Germany2
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P350
  • P305+P351+P338
  • P308+P313
  • P332+P313
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
RTECSAC5960000
Hazard statements
  • H303 May be harmfully swallowed 吞食可能有害
  • H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Hazard Codes T
Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4380 mg/kg
TOXIC EFFECTS :
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   JPPMAB Journal of Pharmacy and Pharmacology.  (Pharmaceutical Soc. of Great
   Britain, 1 Lambeth High St., London SEI 7JN, UK)  V.1-    1949-
   Volume(issue)/page/year: 16,472,1964

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JRPFA4 Journal of Reproduction and Fertility.  (Biochemical Soc. Book Depot,
   POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK)  V.1-    1960-
   Volume(issue)/page/year: 4,219,1962

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Bird - chicken
DOSE/DURATION           : 14 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 20,1242,1970

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 18,645,1968

{hazard_com}

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 10 gm/L
REFERENCE :
   APHGAO Acta Pharmaceutica Hungarica.  (Kultura, POB 149, H-1389 Budapest,
   Hungary)  1953-    Adopts V.24 in 1955.  Volume(issue)/page/year: 56,97,1986

TYPE OF TEST            : DNA inhibition
ROUTE OF EXPOSURE       : Unreported
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 3330 mg/kg
REFERENCE :
   APHGAO Acta Pharmaceutica Hungarica.  (Kultura, POB 149, H-1389 Budapest,
   Hungary)  1953-    Adopts V.24 in 1955.  Volume(issue)/page/year: 56,97,1986

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Cells - not otherwise specified
DOSE/DURATION           : 66 gm/L
REFERENCE :
   APHGAO Acta Pharmaceutica Hungarica.  (Kultura, POB 149, H-1389 Budapest,
   Hungary)  1953-    Adopts V.24 in 1955.  Volume(issue)/page/year: 56,97,1986

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 10 gm/L
REFERENCE :
   CRSUBM Cancer Research Supplement.  (Baltimore, MD)  No.1-4, 1953-56.
   Volume(issue)/page/year: 3,69,1955

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 3250 mg/kg
SEX/DURATION            : female 6-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
   Reproductive - Specific Developmental Abnormalities - body wall
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 30,1557,1980

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 3250 mg/kg
SEX/DURATION            : female 6-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSUR

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 2 gm/kg
SEX/DURATION            : female 15-16 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   85DJA5 "Malformations Congenitales des Mammiferes," Tuchmann-Duplessis, H.,
   Paris, Masson et Cie, 1971  Volume(issue)/page/year: -,95,1971

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其他信息

  • Sigma Aldrich:79-16-3(sigmaaldrich)
  • TCI Shanghai:N-甲基乙酰胺 N-Methylacetamide,>;99.0%(GC)(79-16-3)
  • Alfa Aesar:N-甲基乙酰胺,99% N-Methylacetamide, 99%(79-16-3)
  • 储运特性:库房通风低温干燥
  • 方法一:由乙酸乙酯与甲胺反应而得。将乙酸乙酯和65%的甲胺混合，加热至60℃左右，反应4昼夜，至不再有分层现象，即反应完毕。减压蒸馏回收乙醇，收集95-110℃（4.0kPa）馏分而得N-甲基乙酰胺。
  • 溶于水、乙醇、苯、醚、氯仿，不溶于石油醚。
  • 海关编码:29241900
  • 毒性分级:中毒
  • MSDS 信息:N-Methylacetamide(79-16-3).msds
  • N-甲基乙酰胺价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 M0133 N-甲基乙酰胺 N-Methylacetamide 25G 129元 2014/06/02 M0133 N-甲基乙酰胺 N-Methylacetamide 500G 489元 2010/06/21 126141000 N-甲基乙酰胺 N-Methylacetamide 99+% 100 GR 224元
  • 类别:易燃液体
  • MOL 文件:79-16-3.mol
  • 用途一:用作溶剂，也用于制药
  • 下游产品:替罗非班
  • 用途二:该品为农药、医药等有机合成的中间体。
  • 用途三:因它具有溶解其它有机物的优良机物性能的优良性能，所以在有机合成上常用作溶剂使用在制药工业，使用广泛，如合成孢菌素，就使用它和为溶剂。N-甲基乙酰胺对于某些化学反应有催化作用，在非极性溶剂中又是一个脱酸剂。所以目前使用广泛。
  • 图谱信息:N-甲基乙酰胺(79-16-3)质谱(MS) N-甲基乙酰胺(79-16-3)核磁图( 13 CNMR) N-甲基乙酰胺(79-16-3)核磁图( 1 HNMR) N-甲基乙酰胺(79-16-3)Raman光谱 N-甲基乙酰胺(79-16-3)红外图谱(IR1)
  • 灭火剂:干粉、泡沫、砂土、水
  • Acros Organics:N-甲基乙酰胺 N-Methylacetamide, 99+%(79-16-3)
  • 急性毒性:口服- 大鼠 LD50: 5000 毫克/ 公斤
  • 可燃性危险特性:易燃; 燃烧产生有毒氮氧化物气体

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Amides - Carbonyl Compounds
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Nitrogen Compounds 氮化合物
  5. Protected Amines - Nitrogen Compounds
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Nitrogen Compounds 氮化合物
  5. Protected Amines - Nitrogen Compounds
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Nitrogen Compounds 氮化合物
  5. Polyamines

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