Congo red 刚果红
CAS 573-58-0 MFCD00004028
化学结构图
SMILES: Nc1c(/N=N/c2ccc(-c3ccc(/N=N/c4cc(S(=O)(=O)[O-])c5ccccc5c4N)cc3)cc2)cc(S(=O)(=O)[O-])c2ccccc12.[Na+].[Na+]
化学属性
| Mol. Formula | C32H22N6Na2O6S2 |
|---|---|
| Mol. Weight | 697 |
| Density | 0.995 g/mL at 25 °C |
| Melting Point | >360 |
| TSCA | Yes |
| Solubility | 可溶 |
| Stability | 对湿度敏感 |
| Appearance | 棕红色粉状物，易溶于热水，溶于10份冷水，溶液呈黄红色；溶于乙醇呈橙色；极微溶于丙酮，几乎不溶于醚。溶于乙醇呈橙色，微溶于丙酮。在浓硫酸中呈深蓝色，稀释后呈浅蓝色有蓝针对沉淀。其水溶液加浓盐酸生成戏光蓝色沉淀；加乙酸生成呈蓝光紫色转为较红的蓝色沉淀。在浓烧碱中不溶解。对酸、盐敏感，即使从空气中吸收二氧化碳，也会使色泽变蓝暗，但用稀纯碱液处理可恢复原来色泽。 |
别名和识别编码
| Chemical Name | Congo red |
|---|---|
| CAS Number | 573-58-0 |
| EC Number | 209-358-4 |
| Beilstein Registry Number | 3894858 |
| MDL Number | MFCD00004028 |
| Synonym | 3,3'-[(1,1'-BIPHENYL)-4,4'-DIYLBIS(AZO)]BIS(4-AMINO-1-NAPHTHALENESULFONIC ACID) 2NA 3,3'-[[1,1'-联苯]-4,4'-基双(偶氮)]双(4- 4'-基双(偶氮)]双(4-氨基萘-1-磺酸)二钠 4-二[(偶氮-2)-1-氨基萘-4-磺酸钠 Atlantic C Benzo Congo Red C.I. 22120; Disodium 3,3'-[[1,1'-biphenyl]-4,4'-diylbis(azo)]bis(4-aminonaphthalene-1-sulphonate) C.I.直接红28 CONGO RED CONGO RED 4B Congo Red Congo Red L Congo Red M Congo Red RS Congo Red W DIRECT RED 28 Direct Red 28 Natrium-salz der d Red, Congo {} {} {} {} {} {} {} {} {} {} {} {} {} {} { 二苯基-4,4′-二［(偶氮-2-)-1-氨基萘-4-磺酸钠］ 剛果紅 棉红 B 直接朱红 直接红 28 |
| PubChem Substance ID | 11313 |
| Merck Number | 2498 |
| Chemical Name Translation | 刚果红 |
| Reaxys-RN | 6765909 |
| Wiswesser Line Notation | L66J BZ ESWQ CNUNR DR DNUN- CL66J BZ ESWQ &-NA- 2 |
| LabNetwork Molecule ID | LN00194917 |
| InChI | InChI=1S/C32H24N6O6S2.2Na/c33-31-25-7-3-1-5-23(25)29(45(39,40)41)17-27(31)37-35-21-13-9-19(10-14-21)20-11-15-22(16-12-20)36-38-28-18-30(46(42,43)44)24-6-2-4-8-26(24)32(28)34;;/h1-18H,33-34H2,(H,39,40,41)(H,42,43,44);;/q;2*+1/p-2 |
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分类
- {SA} Analy
- {SNA} C,
- {SNA} All Alphabetically Sorted, All alphabetical sorted, Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Aromatics, C,
- {SNA} C, Indicators, Stains & Dyes, A to Z, Stains and Dyes, Titration,
- {SNA} Additional Standards, All alphabetical sorted, Analytical Standards, Aromatics, Chemical Class,
- {SNA} C, Certified Stains & Dyes, Stains & Dyes, A to Z, Stains and Dyes, 细胞生物学, 血液学和组织学
- {SNA} C, Indicators, Stains & Dyes, A to Z, Stains and Dyes, Titration,
产品应用
- 酸碱指示剂[pH3.0(蓝紫)-5.0(红)]，吸附指示剂，沉淀蛋白质，检测胃液中的游离盐酸、胚胎切片、植物粘蛋白、纤维素、弹性组织等染色，测定硼酸、氰化物和盐酸等。
相关文献及参考
- Merck:14,2498
- Merck:14,2498 Beilstein:16(3)474
安全信息
GHS Symbol
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
- R36 Irritating to eyes 刺激眼睛
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R45 May cause cancer 可能致癌
- R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
- P201 Obtain special instructions before use. 使用前获取专门指示。
- P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
- P203
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P264+P265
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P281 Use personal protective equipment as required. 使用所需的个人防护装备。
- P305+P351+P338
- P308+P313
- P318
- P337+P313
- P337+P317
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- H319 Causes serious eye irritation 严重刺激眼睛
- H350 May cause cancer 可能致癌
- H351 Suspected of causing cancer 怀疑致癌
- H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
- H361d Suspected of damaging the unborn child 怀疑对未出生婴儿造成伤害
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 15200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460) Volume(issue)/page/year: OTS 215154
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Bird - pigeon DOSE/DURATION : 120 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - chronic pulmonary edema Blood - change in clotting factors REFERENCE : AJMSA9 American Journal of the Medical Sciences. (Slack Inc., 6900 Grove Rd., Thorofare, NJ 08086) New series: V.1- 1841- Volume(issue)/page/year: 198,73,1939
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 250 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JOIMA3 Journal of Immunology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1916- Volume(issue)/page/year: 68,53,1952
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 143 mg/kg TOXIC EFFECTS : Vascular - other changes REFERENCE : 34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969 Volume(issue)/page/year: -,185,1969
TYPE OF TEST : LCLo - Lowest published lethal con
TYPE OF TEST : LDLo - Lowes
TYPE OF TEST : DNA adduct ROUTE OF EXPOSURE : Administration onto the skin TEST SYSTEM : Rodent - mouse DOSE/DURATION : 192 umol/kg REFERENCE : CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 5,231,1984
TYPE OF TEST : Unscheduled DNA synthesis TEST SYSTEM : Rodent - hamster Liver DOSE/DURATION : 10 umol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 136,255,1984
TYPE OF TEST : DNA inhibition TEST SYSTEM : Microorganism - not otherwise specified DOSE/DURATION : 110 mg/L REFERENCE : NNBYA7 Nature (London), New Biology. (Basingstoke, Hants., UK) V.229-246, 1971-73. For publisher information, see NATUAS. Volume(issue)/page/year: 232,143,1971
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 33 ug/plate REFERENCE : CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 3,21,1982
TYPE OF TEST : Unscheduled DNA synthesis TEST SYSTEM : Rodent - rat Liver DOSE/DURATION : 10 umol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 136,255,1984
TYPE OF TEST : Body fluid assay TEST SYSTEM : Rodent - rat Bacteria - Salmonella typhimurium DOSE/DURATION : 300 mg/kg REFERENCE : IAEHDW International Archives of Occupational and Environmen
TYPE OF TEST
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED
{TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE : 140 mg/kg SEX/DURATION : female 9 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) REFERENCE : PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 117,176,1964
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE : 1500 mg/kg SEX/DURATION : female 8-12 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - physical REFERENCE : TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980- Volume(issue)/page/year: 4,403,1984
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE : 5 gm/kg SEX/DURATION : female 8-12 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - physical REFERENCE : TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980- Volume(issue)/page/year: 4,403,1984
TYPE OF TEST : TDLo - Low
其他信息
- 下游产品:2-吡啶甲酸 --> 三(2-氨基乙基)胺 --> 猪去氧胆酸 --> 亚油酸乙酯 --> 氟氢化铵 --> 8-氮鸟嘌呤 --> N-CBZ-L-丙氨酸 --> 硝基丙二酸二乙酯 --> 2-甲基丙氨酸
- Acros Organics:直接红/刚果红 Congo Red, Indicator grade(573-58-0)
- 溶于水呈黄红色，溶于水呈黄红色，溶于乙醇呈橙色，极微溶于丙酮，几乎不溶于乙醚。最大吸收波长(pH7.3)488nm(E1cm1%) 595。半数致死量(大鼠，静脉)190mg/kg。
- MOL 文件:573-58-0.mol
- 刚果红价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 71011181 刚果红;直接刚果红; 煮大红; 棉红; 直接朱红; 直接大红; 二苯基-4,4′-二［(偶氮2)-1-氨基萘-4-磺酸钠］ 25g 135元 2011/08/23 71011154 刚果红;直接刚果红; 煮大红; 棉红; 直接朱红; 直接大红; 二苯基-4,4′-二［(偶氮2)-1-氨基萘-4-磺
- 上游原料:硫酸钠 --> 硫酸化蓖麻油 --> 联苯胺 --> 对氨基萘磺酸
- 用途三:酸碱指示剂[pH3.0(蓝紫)-5.0(红)]，吸附指示剂，沉淀蛋白质，检测胃液中的游离盐酸、胚胎切片、植物粘蛋白、纤维素、弹性组织等染色，测定硼酸、氰化物和盐酸等。
- 图谱信息:直接红 28(573-58-0)核磁图( 1 HNMR) 直接红 28(573-58-0)红外图谱(IR1) 直接红 28(573-58-0)核磁图( 13 CNMR) 直接红 28(573-58-0)红外图谱(
- 人工染料:即苯胺染料或煤焦油染料，种类很多，应用极广。它的缺点是经日光照射容易褪色，苯胺蓝、亮绿、甲基绿等更易褪色。在制片中注意掌握酸碱度，并避免日光直射，也能经几年不褪色。 刚果红(英文Congo red)是酸性染料，呈枣红色粉末状，能溶于水和酒精，遇酸呈蓝色。能作染
- 方法一:由联欢苯胺重氮化后，与1，4-氨基萘磺酸钠进行偶合，而后经盐析、过滤及干燥而制得。具体操作为：取48.4g联苯胺溶于300ml盐酸（含浓盐酸20ml）中，加冰冷至5℃以下，加30ml浓盐酸后，加入由14.4g亚硝酸钠配成的10%的水溶液。重氮化结束后，将重氮盐溶液慢慢加入150g对氨基萘磺酸钠和少量水配成的溶液中，放置半小时后，在充分搅拌下慢慢加入35g碳酸钠，使溶液呈碱性，加热至约80℃后，冷却，过滤，用饱和盐水洗涤，干燥即得成品。工业制备原料消耗（kg/t）联苯胺（100%） 200氨基萘磺酸钠（100%） 520亚硝酸钠（工业） 160盐酸（31%） 330纯碱（工业） 340精盐 2500太古油 9乙醇 60乙酸钠 35元明粉 50
- 用途二:曾广泛用于棉、粘胶的染色，因其遇酸极易转变为蓝色，以及无适当处理方法使之提高其湿处理牢度，故自不溶性偶氮染料和直接耐酸大红4BS问世以来，该品在染色中的使用量逐减减少，但在造纸工业中用量颇大。还可作为酸碱指标剂，即刚果红试纸，pH3.0（蓝紫）-5.0（红）。另外还用于生物染色，分析试剂。
- 人工染料:即苯胺染料或煤焦油染料，种类很多，应用极广。它的缺点是经日光照射容易褪色，苯胺蓝、亮绿、甲基绿等更易褪色。在制片中注意掌握酸碱度，并避免日光直射，也能经几年不褪色。 刚果红(英文Congo red)是酸性染料，呈枣红色粉末状，能溶于水和酒精，遇酸呈蓝色。能作染料，也用作指示剂。在植物制片中常作为苏木精或其他细胞染料的衬垫剂。用来染细胞质时，能把胶制或纤维素染成红色。在动物组织制片中用来染神经轴、弹性纤维、胚胎材料等。另外刚果红可以跟苏木静作二重染色，也可用作类淀粉染色，由于它能溶于水和酒精，所以洗涤和脱水处理要迅速。
- 用途一:主要用于棉、麻、丝等纺织和纸制品的染色，也可用作指示剂
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