1-Methylimidazole 1-甲基咪唑

CAS 616-47-7 MFCD00005292

化学结构图

616-47-7
SMILES: Cn1ccnc1

化学属性

Mol. FormulaC4H6N2
Mol. Weight82
Refractive index1.4920 to 1.4980
Boiling Point198
Density1.03
Melting Point-6
Autoignition Point977 °F
Vapor Pressure0.4 mmHg ( 20 °C)
Flash Point92°C(lit.)
TSCAYes
Appearance 外观:无色透明液体,熔点:-60℃,沸点:198℃, 密度d20/4=1.036g/ml。 含量:≥99% 。
Stability易吸潮

别名和识别编码

Chemical Name1-Methylimidazole
Beilstein Registry Number105197
CAS Number616-47-7
PubChem Substance ID1390
EC Number210-484-7
MDL NumberMFCD00005292
Synonym 1-Methyl-1H-imidazole; Methyl imidazole; N-Methylimidazole N-Methylimidazole N-甲基咪唑 N-甲基咪唑,1-甲基-1H-咪唑 Imidazole, 1-methyl- 1-methyl-1h-imidazol 1-甲基-1H-咪唑 CAP B (1-METHYLIMIDAZOLE 10% IN N-METHYLIMIDAZOLE N-methyl glyoxaline 1-甲基咪唑 1H-Imidazole, 1-methyl- CAP B (1-METHYLIMIDAZOLE 12% IN ACETONIT 1-methyl-1h-imidazole 1-甲基咪唑(5KG禁止空运) 1-METHYLIMIDAZOLE, FOR DNA SYNTHESIS methyl imidazole CAP B (1-METHYLIMIDAZOLE 10% IN THF)* 1-甲咪唑 1-METHYLIMIDAZOLE 1-methylimidazole solution 1-Methylimidazole, >=99%, purified by redistillation 1-Methylimdazole 甲基引咪唑 {Chemicalbook
Chemical Name Translation1-甲基咪唑
Reaxys-RN105197
Wiswesser Line NotationT5N CNJ A1
LabNetwork Molecule IDLN00195885
InChIInChI=1S/C4H6N2/c1-6-3-2-5-4-6/h2-4H,1H3
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分类

  • {SNA} Building Blocks, C3 to C8, Chemical Synthesis, Heterocyclic Building Blocks, Imidazoles
  • {SNA} A to C, Biochemicals and Reagents, Building Blocks, C3 to C8, Carbonate dehydratase, Chemical Synthesis, D to K, Enzyme Inhibitors, Enzyme Inhibit

产品应用

  • 有机合成中间体和用作环氧树脂固化剂、粘合剂等;可广泛用于环氧树脂粘接、涂装、浇注、包封、浸渍及复合材料等。

相关文献及参考

  • Reacts with acid chlorides, including chloroformates, to give N-acylimidazolium salts, which are useful reagents for the acylation of, for example, amino acids: Bull. Soc. Chim. Fr., 1021 (1973).
  • Useful base for peptide coupling, etc. See, e.g.: J. Chem. Soc., Chem. Commun., 2223 (1995). For peptide reagents, see Appendix 6.
  • Undergoes lithiation at the 2-position. Reaction of the Li derivative with ketones followed by dehydration with acetic anhydride is a good route to 2-alkylideneimidazoles: Synthesis, 78 (1990). Likewise, reaction with benzonitrile gives the 2-benzoyl derivative, the carbonyl group of which undergoes Wittig methylenation: Synth. Commun., 20, 321 (1990).
  • Beilstein:23,46

安全信息

GHS Symbol
WGK Germany1
Hazard Codes 8 C T,C,Xn Xn;C
Hazard statements
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H412 Harmfutoaquaticlifewithlonglastingeffects 对水生生物有害并具有长期影响。
  • H302 Harmful if swallowed 吞食有害
  • H311 Toxic in contact with skin 皮肤接触中毒
  • H312 Harmful in contact with skin 皮肤接触有害
  • H227 Combustible liquid 可燃液体
Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSNI7000000
Precautionary statements
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312+P330
  • P301+P330+P331
  • P303+P361+P353
  • P303+P361+P353+P310+P363
  • P304+P340
  • P304+P340+P310
  • P305+P351+P338
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
Risk Statements
  • R11 Highly flammable 非常易燃
  • R19 May form explosive peroxides 可能生成易爆的过氧化物质
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
  • R21 Harmful in contact with skin 与皮肤接触有害
  • R21/22 Harmful in contact with skin and if swallowed 皮肤接触和不慎吞咽有害
  • R22 Harmful if swallowed 吞咽有害
  • R24 Toxic in contact with skin 与皮肤接触有毒
  • R34 Causes burns 会导致灼伤
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Packing GroupII
UN Number 1760 3267 UN2922
Storage condition Store at RT. 密封保存 Hygroscopic
Hazard Class8
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 380 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   14,301,1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1400 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   14,301,1969

其他信息

  • 上游原料:咪唑 --> 碳酸二甲酯 --> 4-氯-3-硝基苯甲酸
  • Sigma Aldrich:616-47-7(sigmaaldrich)
  • TCI Shanghai:1-甲基-1H-咪唑 1-Methylimidazole,>;99.0%(GC)(616-47-7)
  • F:3-10
  • MSDS 信息:1-Methyl-1H-imidazole(616-47-7).msds
  • 下游产品:毒死蜱 --> 1-甲基咪唑-5-甲酰氯盐酸盐 --> 1-甲基-1H-咪唑-2-羧酸 --> 甲基毒死蜱 --> 1-丁基-3-甲基咪唑六氟磷酸盐 --> 1-丁基-3-甲基咪唑四氟硼酸盐 --> 硝唑芬酮 --> 1-甲基-1H-咪唑-2-甲醛 --> 1-乙基-3-甲基咪唑四氟硼酸盐 --> 1-乙基-3-甲基咪唑二氨腈,98% --> 2-(1-甲基-1H-咪唑-2-基)-2-羰基乙酸乙酯 --> 洛沙坦 --> 1-甲基-1H-咪唑-2-甲酸乙酯 --> 1-乙基-3-甲基咪唑啉双(三氟甲基磺酰基)亚胺 --> 盐酸萘甲唑啉 --> 1-丁基-3-甲基咪唑溴盐
  • 用途一:用作有机合成中间体和树脂固化剂、粘合剂等
  • 蒸气压:0.4 mm Hg ( 20 °C)
  • 图谱信息:N-甲基咪唑(616-47-7)核磁图( 13 CNMR) N-甲基咪唑(616-47-7)核磁图( 1 HNMR) N-甲基咪唑(616-47-7)红外图谱(IR1) N-甲基咪唑(616-47-7)质谱(MS)
  • 用途二:主要用于环氧树脂和其它树脂的固化剂;用于浇注、粘接和玻璃钢等领域。
  • 用途三:有机合成中间体和用作环氧树脂固化剂、粘合剂等;可广泛用于环氧树脂粘接、涂装、浇注、包封、浸渍及复合材料等。
  • Acros Organics:N-甲基咪唑 1-Methylimidazole, 99%(616-47-7)
  • 溶于水,溶于有机溶剂。
  • 敏感性:Hygroscopic
  • N-甲基咪唑价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 xw010195 1-甲基咪唑;N-甲基咪唑;1-甲基甘噁啉 100g 160元 2011/08/23 xw010206 1-甲基咪唑;N-甲基咪唑;1-甲基甘噁啉 500g 398元 2011/08/23 C126991000 1-甲基咪唑 99% 100g 388元
  • MOL 文件:616-47-7.mol
  • 检测方法:GC,NMR
  • 海关编码:29332990
  • Alfa Aesar:1-甲基咪唑,99% 1-Methylimidazole, 99%(616-47-7)

系列性分类