Hypoxanthine 次黄嘌呤

CAS 68-94-0 MFCD00005725

化学结构图

68-94-0
SMILES: O=c1[nH]cnc2nc[nH]c12

化学属性

Mol. FormulaC5H4N4O
Mol. Weight136.11
Density1.89
Melting Point250°C
TSCAYes
Solubility难溶
Appearance powder
Boiling Point533.4°C at 760 mmHg

别名和识别编码

Chemical NameHypoxanthine
CAS Number68-94-0
Synonym Hypoxanthine {LY} Hypoxanthine {} {LY} Hypoxanthine {} {} {LY} Hypoxanthine {} {} {} {LY} Hypoxanthine {} {} {} {} {LY} Hypoxanthine {} {} {} {} {} {LY} Hypoxanthine {} {} {} {} {} {} {LY} Hypoxanthine {} {} {} {} {} {} {} {LY} Hypoxanthine {} {} {} {} {} {} {} {} {LY} Hypoxanthine {} {} {} {} {} {} {} {} {} {LY} Hypoxanthine {} {} {} {} {} {} {} {} {} {} {LY} Hypoxanthine {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {LY} Hypoxanthine {} {} {} {} {} {} {} {} {} {} {} {} {LY} Hypoxanthine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Hypoxanthine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Hypoxanthine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Hypoxanthine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Hypoxanthine
EC Number200-697-3
Beilstein Registry Number5811
MDL NumberMFCD00005725
PubChem Substance ID135398638
Merck Number4869
Reaxys-RN608599
Chemical Name Translation次黄嘌呤
Wiswesser Line NotationT56 BN DM FVM INJ
LabNetwork Molecule IDLN00195829
InChIInChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10)
Canonical SMILESO=C1NC=NC2=C1N=CN2
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分类

  • {SNA} Analytical Standards, Chromatography, EP Standards, EP Standards C - D, Pharmaceutical Standards, Pharmacopeia Standards, 分析/色谱
  • {SNA} Conditioned Media, Media Supplements and Reagents, Hybridoma Reagents, 细胞培养, 试剂和添加剂
  • {SNA} Nucleoside Analogs, 核苷,核苷酸和寡核苷酸, 生化试剂
  • {SA} Biochemicals and Reagents, Nucleoside Analogs, Nucleosides, N
  • Heterocycles
  • {SNA} Cell Culture, Conditioned Media, Media Supplements and Reagents, Hybridoma Reagents, Reagents and Supplements
  • {SNA} Analytical Standards, EP Standards, EP Standards C - D,
  • {SNA} Biochemicals and Reagents, Nucleoside Analogs, Nucleosides, Nucleotides, Oligonucleotides
  • {uni_hamburg} no charge; nitrogen heterocycle; aromatic; large ring; fused rings; 5ring;

产品应用

  • 生化试剂,制备生物培养基。

相关文献及参考

  • Jansen, R., et al.: Clin. Biochem., 38, 362 (2005),
  • Merck: 14,4869
  • Merck: 14,4869 Beilstein:26,416
  • Short: III/20a
  • Short: III/31a
  • [1]. Saugstad OD, et al. Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical production. Pediatr Res. 1988 Feb;23(2):143-50.

安全信息

Signal word Warning
GHS Symbol
WGK Germany3
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘;
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护;
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312
  • P302+P352
  • P305+P351+P338
RTECSUP0791000
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Hazard Codes Xn
Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 750 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: AD691-490

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 600 mg/kg
SEX/DURATION            : female 13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   JJPAAZ Japanese Journal of Pharmacology.  (Japanese Pharmacological Soc.,
   c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto
   606, Japan)  V.1-    1951-  Volume(issue)/page/year: 22,201,1972

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 1 gm/kg
SEX/DURATION            : female 13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   JJPAAZ Japanese Journal of Pharmacology.  (Japanese Pharmacological Soc.,
   c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto
   606, Japan)  V.1-    1951-  Volume(issue)/page/year: 22,201,1972

其他信息

  • 方法一:氰乙酸乙酯与乙醇钠、硫脲经环合反应得到2-巯基-4-氨基-6-羟基嘧啶,再经亚硝化、还原、消除、环合,制得6-羟基嘌呤。
  • 下游产品:腺嘌呤 --> 阿昔洛韦 --> 6-巯基嘌呤 --> 6-苄胺基嘌呤 --> 6-氰嘌呤 --> 6-溴嘌呤 --> 6-苄氨基嘌呤 --> 6-碘嘌呤 --> 6-二甲基氨基嘌呤 --> 6-巯基嘌呤(一水合物)
  • MSDS 信息:6-Hydroxypurine(68-94-0).msds
  • 6-羟基嘌呤价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 65009631 次黄嘌呤(+4℃) 1g 44.7元 2011/08/23 SH963601 次黄嘌呤;次黄碱;6-氧嘌呤;6-羟基嘌呤 1g 216元 2011/04/16 H0311 次黄嘌呤 Hypoxanthine 25G 582元
  • 外观性质:无色针状结晶。100ml水19℃时溶解0.07g,100℃时溶解1.4g。溶于稀酸和稀碱。在150℃时分解而不熔融。pH4~7时最大吸收波长249.5mn。ε 10700。最小吸收波长221nm。吸光度比值A250/A260=1.32,A280/A260=0.09,A290/A260=0.01。半数致死量(小鼠,腹腔)750mg/kg。熔点:250℃
  • Hazard Note:Harmful
  • Sigma Aldrich:68-94-0(sigmaaldrich)
  • 上游原料:氰乙酸乙酯 --> 硫脲 --> 乙醇钠 --> 6-氨基-2-硫脲嘧啶
  • 100ml水19℃时溶解0.07g,100℃时溶解1.4g。溶于稀酸和稀碱。在150℃时分解而不熔融。pH4~7时最大吸收波长249.5mn。ε 10700。最小吸收波长221nm。吸光度比值A250/A260=1.32,A280/A260=0.09,A290/A260=0.01。半数致死量(小鼠,腹腔)750mg/kg。
  • MOL 文件:68-94-0.mol
  • Acros Organics:次黄嘌呤 Hypoxanthine, 99.5%(68-94-0)
  • 用途二:用作巯嘌呤和硫唑嘌呤的原料
  • 用途三:生化试剂,制备生物培养基。
  • Alfa Aesar:次黄嘌呤,99% Hypoxanthine, 99%(68-94-0)
  • TCI Shanghai:次黄嘌呤 Hypoxanthine,>;98.0%(LC)(E)(68-94-0)
  • 用途一:抗恶性肿瘤药6-巯嘌呤的中间体。

系列性分类