Uridine 尿嘧啶核苷

CAS 58-96-8 MFCD00006526

化学结构图

58-96-8
SMILES: O=c1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)[nH]1

化学属性

Mol. FormulaC9H12N2O6
Mol. Weight244.20
Density1.1
Melting Point163-167°C
TSCAYes
Appearance powder 白色针状结晶或粉末。无气味,味稍甜而微辛。mp165℃。比旋度+4°(20℃,C=2,水中)。系核苷类的一种。能溶于水,微溶于稀醇,不溶于无水乙醇。
SolubilityH2O: 50 mg/mL
Refractive index9 ° (C=2, H2O)
Boiling Point387.12 °C at 760 mmHg

别名和识别编码

Chemical NameUridine
CAS Number58-96-8
Alfabeta NameURIDINE
MDL NumberMFCD00006526
Synonym Uridine {LY} Uridine {} {LY} Uridine {} {} {LY} Uridine {} {} {} {LY} Uridine {} {} {} {} {LY} Uridine {} {} {} {} {} {} {} {} {} {} {LY} Uridine {} {} {} {} {} {} {LY} Uridine {} {} {} {} {} {} {} {LY} Uridine {} {} {} {} {} {} {} {} {LY} Uridine {} {} {} {} {} {} {} {} {} {LY} Uridine {} {} {} {} {} {} {} {} {} {} {LY} Uridine {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {LY} Uridine {} {} {} {} {} {} {} {} {} {} {} {} {LY} Uridine {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Uridine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Uridine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Uridine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Uridine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
EC Number200-407-5
Beilstein Registry Number754902
PubChem Substance ID6029
Merck Number9877
Reaxys-RN754904
Chemical Name Translation尿嘧啶核苷
LabNetwork Molecule IDLN00008482
InChIInChI=1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7-,8-/m1/s1
Canonical SMILESO[C@H]1[C@@H](O)[C@H](N2C(NC(C=C2)=O)=O)O[C@@H]1CO
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分类

  • {SNA} Biochemicals and Reagents, Cell Biology, Nucleosides, Nucleosides, Nucleotides, Oligonucleotides, Nutrition Research, Panax ginseng, Phytochemicals by Plant (Food/Spice/Herb)
  • {uni_hamburg} no charge; oxygen heterocycle; nitro
  • Heterocycles
  • Nucleotides
  • Carbohydrates & Derivatives
  • {SNA} Cell Culture, Miscellaneous Reagents and Supplements, Reagents and Supplements
  • {Chemicalbook} 生物化学品: 核酸类: 核苷及其衍生物
  • {SNA} Miscellaneous Reagents and Supplements, 细胞培养, 试剂和添加剂
  • {SNA} Nucleosides, Panax ginseng, Phytochemicals by Plant (Food/Spice/Herb), 核苷,核苷酸和寡核苷酸, 生化试剂, 细胞生物学, 营养研究
  • Bases & Related Reagents,
  • {SNA} Biochemicals and Reagents, Nucleosides, Nucleosides, Nucleotides, Oligonucleotides,

产品应用

  • 尿苷是一种药物,如抗巨型红血球贫血,治疗肝;脑血管;心血管等疾病,也是制造氟尿嘧啶(S-FC);脱氧核苷;碘苷(IDUR);溴苷(BUDR);氟苷(FUDR)等药物的主要原料。

相关文献及参考

  • Merck:14,9877
  • Short: III/20a
  • Merck:14,9877 Beilstein:31,23
  • Short: III/10a
  • Lorine, P., et al.: J. Biol. Chem., 178, 439 (1949); Grakoui, A., et al.: J. Virol., 63, 5216 (1989); Strauss, J., et al.: Microbiol. Rev., 58, 491 (1994); Lin, Y., et al.: Virology, 292, 78
  • Short: III/5a

安全信息

Warnings IRRITANT
Signal word Warning
GHS Symbol
WGK Germany3
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触;
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛,皮肤或衣服。
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RTECSYR1450000
Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4335 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - changes in motor activity (specific assay)
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 207,504,1978

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 740 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 301,45,1993

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Mammal - species unspecified Lymphocyte
DOSE/DURATION           : 100 mmol/L
REFERENCE :
   PNASA6 Proceedings of the National Academy of Sciences of the United States
   of America.  (National Academy of Sciences, Printing & Pub. Office, 2101
   Constitution Ave., Washington, DC 20418) V.1-    1915-
   Volume(issue)/page/year: 48,686,1962

其他信息

  • 用途三:尿苷是一种药物,如抗巨型红血球贫血,治疗肝、脑血管、心血管等疾病,也是制造氟尿嘧啶(S-FC)、脱氧核苷、碘苷(IDUR)、溴苷(BUDR)、氟苷(FUDR)等药物的主要原料。
  • 尿苷价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 65012581 尿苷;尿嘧啶核苷;二氢嘧啶核苷;尿核苷;1-β-D-呋喃核糖基尿嘧啶;NFDB2NFDB3-1-β-D-呋喃核苷 5g 295元 2011/08/23 SU375001 尿苷;尿嘧啶核苷;二氢嘧啶核苷;尿核苷;1-β-D-呋喃核糖基尿嘧啶;NFDB2NFDB3-1-β-D-呋喃核苷 1g 330元 2011/04/16 U0020 尿嘧啶核苷 Uridine 25G 925元
  • 比旋光度:8.4 ° (c=2,water)
  • Alfa Aesar:尿(嘧啶核)苷,99% Uridine, 99%(58-96-8)
  • 用途一:用于制造氟尿嘧啶脱氧核苷、碘苷等抗肿瘤药物
  • MOL 文件:58-96-8.mol
  • 无气味。味稍甜而微辛。能溶于水,微溶于稀醇,不溶于无水乙醇。构成动物细胞核酸的有关成分。
  • 用途二:本品可用于巨型红血球贫血,也可与其他核苷、碱基合用于治疗肝、脑血管及心血管等疾患。
  • Acros Organics:脲嘧啶核苷/尿苷 Uridine,99%(58-96-8)
  • 图谱信息:尿苷(58-96-8)Raman光谱 尿苷(58-96-8)核磁图( 13 CNMR) 尿苷(58-96-8)核磁图( 1 HNMR) 尿苷(58-96-8)红外图谱(IR1) 尿苷(58-96-8)红外图谱(IR2)
  • 检测方法:HPLC
  • 用途四:尿苷是一种药物,如抗巨型红血球贫血,治疗肝;脑血管;心血管等疾病,也是制造氟尿嘧啶(S-FC);脱氧核苷;碘苷(IDUR);溴苷(BUDR);氟苷(FUDR)等药物的主要原料。
  • TCI Shanghai:尿(嘧啶核)苷 Uridine,>;98.0%(T)(58-96-8)
  • F:10
  • MSDS 信息:Uridine(58-96-8).msds
  • Hazard Note:Keep Cold
  • 下游产品:阿糖腺苷 --> 5'-核糖核苷酸钙
  • Sigma Aldrich:58-96-8(sigmaaldrich)

系列性分类


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