Guanosine 鸟嘌呤核苷

CAS 118-00-3 MFCD00010182

化学结构图

118-00-3
SMILES: Nc1nc2c(ncn2[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)[nH]1

化学属性

Mol. FormulaC10H13N5O5
Mol. Weight283.24
Melting Point250°C
TSCAYes
SolubilitySoluble in Formic Acid:Water (1:1): 50 mg/mL
Density2.25
Appearance 白色或类白结晶性粉末。熔点250℃。
Refractive index-76 ° (C=1, 1mol/L NaOH)
Boiling Point425.8 °C at 760 mmHg

别名和识别编码

Chemical NameGuanosine
MDL NumberMFCD00010182
CAS Number118-00-3
Synonym Guanosine {LY} Guanosine {} {LY} Guanosine {} {} {LY} Guanosine {} {} {} {LY} Guanosine {} {} {} {} {LY} Guanosine {} {} {} {} {} {LY} Guanosine {} {} {} {} {} {} {LY} Guanosine {} {} {} {} {} {} {} {LY} Guanosine {} {} {} {} {} {} {} {} {LY} Guanosine {} {} {} {} {} {} {} {} {} {LY} Guanosine {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {LY} Guanosine {} {} {} {} {} {} {} {} {} {} {} {LY} Guanosine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Guanosine {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Guanosine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Guanosine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Guanosine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Guanosine {} {} {
PubChem Substance ID135398635
Beilstein Registry Number625911
EC Number204-227-8
Merck Number4566
Reaxys-RN567157
Chemical Name Translation鸟嘌呤核苷
InChIKeyNYHBQMYGNKIUIF-UUOKFMHZSA-N
Wiswesser Line NotationT56 BN DN FMYMVJ GUM D- BT5OTJ CQ DQ E1Q
LabNetwork Molecule IDLN00190052
InChIInChI=1S/C10H13N5O5/c11-10-13-7-4(8(19)14-10)12-2-15(7)9-6(18)5(17)3(1-16)20-9/h2-3,5-6,9,16-18H,1H2,(H3,11,13,14,19)/t3-,5-,6-,9-/m1/s1
Canonical SMILESOC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(N=C(N)NC3=O)=C3N=C2)O1
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分类

  • {SNA} Allium sativum (Garlic), Biochemicals and Reagents, Cell Biology, Nucleoside Analogs, Nucleosides, Nucleotides, Oligonucleotides, Nutrition Research, Phytochemicals by Plant (Food/Spice/Herb)
  • {SNA} Core Bioreagents,
  • {SNA} Core Bioreagents, General Reagents, Life Science Reagents for DNA/RNA E
  • {SA} Cell Culture, Core Bioreagents,
  • {SNA} Core Bioreagents, General Reagents, Life Science Reagents for DNA/RNA Electrophoresis, Life Science Reagents for Transfection, Miscellaneous Reagents and Supplements, Research Essentials,
  • {SNA} Allium sativum (Garlic), Nucleoside Analogs, Phytochemicals by Plant (Food/Spice/Herb), 核苷,核苷酸和寡核苷酸, 生化试剂, 细胞生物学,

产品应用

  • 作为GMP, GDP, GTP 和 cGMP的前体,用在细胞培养中

相关文献及参考

  • Beilstein:31,28
  • [1]. De Clercq E1. Guanosine analogues as anti-herpesvirus agents. Nucleosides Nucleotides Nucleic Acids. 2000 Oct-Dec;19(10-12):1531-41.

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P301+P310
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P330 Rinse mouth. 漱口
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
RTECSMF8750000
Signal word Danger
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
Hazard Codes 6.1 T T,Xi
Risk Statements
  • R25 Toxic if swallowed 吞咽有毒
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Packing GroupIII
UN Number 2811 UN 2811 6.1/PG 3
Storage condition 2-8°C, protect from light {LY} 2-8°C, protect from light Store at RT. {} {LY} 2-8°C, protect from light {} {} {LY} 2-8°C, protect from light {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, prote
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 180 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#03206

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: AD277-689

TYPE OF TEST            : Phage inhibition capacity
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 1 gm/L
REFERENCE :
   ZAPOAK Zeitschrift fuer Allgemeine Mikrobiologie.  (Akademie-Verlag GmbH,
   Postfach 1233, Berlin DDR-1086 Ger. Dem. Rep.)  V.1-    1960-
   Volume(issue)/page/year: 12,583,1972

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Human Cells - not otherwise specified
DOSE/DURATION           : 1 mmol/L
REFERENCE :
   JIDEAE Journal of Investigative Dermatology.  (Williams & Wilkins Co., 428
   E. Preston St., Baltimore, MD 21202)  V.1-    1938- Volume(issue)/page/year:
   65,52,1975

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 750 mg/kg
SEX/DURATION            : female 13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   JJPAAZ Japanese Journal of Pharmacology.  (Japanese Pharmacological Soc.,
   c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto
   606, Japan)  V.1-    1951-  Volume(issue)/page/year: 22,201,1972

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 750 mg/kg
SEX/DURATION            : female 10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   JJPAAZ Japanese Journal of Pharmacology.  (Japanese Pharmacological Soc.,
   c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto
   606, Japan)  V.1-    1951-  Volume(issue)/page/year: 22,201,1972

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 1 gm/kg
SEX/DURATION            : female 13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
   Reproductive - Specific Developmental Abnormalities - other developmental
   abnormalities
REFERENCE :
   JJPAAZ Japanese Journal of Pharmacology.  (Japanese Pharmacological Soc.,
   c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto
   606, Japan)  V.1-    1951-  Volume(issue)/page/year: 22,201,1972

其他信息

  • 比旋光度:-62 ° (c=3, in 0.1 N NaOH)
  • 下游产品:阿昔洛韦 --> 利巴韦林 --> 5'-鸟苷酸二钠 --> 5'-核糖核苷酸钙 --> 鸟苷酸 --> 7-甲基鸟嘌呤 --> N,9-二乙酰鸟嘌呤
  • 9-beta-D-呋喃核苷鸟嘌呤价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 65008360 鸟苷 25g 100元 2011/08/23 65008334 鸟苷 25g 100元 2011/04/16 G0171 鸟嘌呤核苷 Guanosine 100G 1650元
  • Sigma Aldrich:118-00-3(sigmaaldrich)
  • TCI Shanghai:鸟嘌呤核苷 Guanosine,>;98.0%(LC)(T)(118-00-3)
  • 用途一:主要用于制造无环鸟苷、三氧唑核苷、三磷酸鸟苷钠等药物的主要原料。
  • F:10-23
  • Hazard Note:Irritant
  • MOL 文件:118-00-3.mol
  • Acros Organics:鸟嘌呤核苷/鸟苷 Guanosine hydrate, 99%(118-00-3)
  • 用途二:工业上主要用于制造无环鸟苷、三氧唑核苷、三磷酸鸟苷钠等药物的主要原料。
  • Alfa Aesar:鸟苷,98+% Guanosine, 98+%(118-00-3)
  • 微溶于水,不溶于乙醇、乙醚。溶于乙酸。
  • MSDS 信息:2-Amino-9-beta-D-ribofuranosyl-9H-purine-6-(1H)-one hydrate(118-00-3).msds
  • 海关编码:29349990
  • 图谱信息:9-beta-D-呋喃核苷鸟嘌呤(118-00-3)质谱(MS) 9-beta-D-呋喃核苷鸟嘌呤(118-00-3)核磁图( 13 CNMR) 9-beta-D-呋喃核苷鸟嘌呤(118-00-3)红外图谱(IR2) 9-beta-D-呋喃核苷鸟嘌呤(118-00-3)核磁图( 1 HNMR) 9-beta-D-呋喃核苷鸟嘌呤(118-00-3)红外图谱(IR1)

系列性分类


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