Aniline 苯胺

CAS 62-53-3 MFCD00007629

化学结构图

62-53-3
SMILES: NC1CCCCC1

化学属性

Mol. FormulaC6H7N
Mol. Weight93
Refractive index1.5840 to 1.5890
Boiling Point181-185
Density1.021
Melting Point-6
Flash Point75°C(lit.)
TSCAYes
SolubilitySoluble in water
Autoignition Point1139 °F
Vapor Density3.22 (185 °C, vs air)
Vapor Pressure0.7 mmHg ( 25 °C)
Stability对光敏感
pH:A

别名和识别编码

Chemical NameAniline
CAS Number62-53-3
PubChem Substance ID6115
EC Number200-539-3
Beilstein Registry Number12(4)223
MDL NumberMFCD00007629
Synonym amino-benzen 胺基苯 NCI 176889 Benzene, amino 氨基苯、阿尼林 Aminobenzol 阿尼林 PHENYLAMINE ai3-03053 Aminobenzene; Phenylamine Β-優卡因 aniline15 AKOS BBS-00003680 Anilin Aniline (benzenamine) Huile d'aniline BENZENAMINE anilina(italian,polish) 氨基苯 anyvim 阿尼林,阿尼林油,胺基苯,氨基苯 苯胺 ANILINE 阿尼林;阿尼林油;胺基苯;氨基苯 Aminobenzene BENZENEAMINE 苯胺标液 ANILINE OIL Kyanol 阿尼林油 RCRA waste number U012 benzenamine anilineandhomologues aniline phenylamine 苯胺, ACS, 99+% Blue Oil Benzidam 苯胺标准溶液 C.I. 76000 C.I. Oxidation Base 1 苯胺, 99+% Benzenamine 安尼林 NCI-C03736 Aminophen Anyvim Aniline reagent Aniline oil Benzene, amino- aniline(andhomologs) ANILINE 苯胺038-01[6] Phenylamine anilin(czech) Aniline and homologues AMINOBENZENE Anilina Krystallin C6H7N (aniline) Aniline(benzenamine) 苯胺 aminobenzene 胺苯 Cyanol
Merck Number659
Chemical Name Translation苯胺
Reaxys-RN605631
Wiswesser Line NotationZR
LabNetwork Molecule IDLN00196257
InChIInChI=1S/C6H7N/c7-6-4-2-1-3-5-6/h1-5H,7H2
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分类

  • A, A-B, AM to AQ, Alpha Sort, Alphabetic, Amines, Analytical Standards, Analytical/Chromatography, Aromatics, Chemical Class, Chromatography, Environmental Standards, Volatiles/ Semivolatiles
  • {Chemicalbook} 农药中间体: 杀菌剂中间体: 其他类杀菌剂
  • {uni_hamburg} no charge; carbocycle; aromatic; 6RingOnly; 6ring; 1fragment
  • {SNA} Essential Chemicals, Inorganic Salts, Solutions and Reagents, Reagent Plus, Research Essentials

产品应用

  • 用作弱碱,能以氢氧化物的形态沉淀三价和四价元素(Fe3+ 、Al3+ 、Cr3+)的易水解盐类,使与难水解的二价元素(Mn2+)的盐类分离。在显微微晶分析中,用以检验能生成硫氰酸络合阴离子或其他阴离子(这些阴离子都能被苯胺沉淀)的元素(Cu、Mg、Ni、Co、Zn、Cd、Mo、W、V)。

相关文献及参考

  • Merck: 14,659
  • Short: II/19c
  • Merck: 14,659 Beilstein: 12,IV,223
  • Short: II/14a
  • Short: II/19b

安全信息

GHS Symbol
WGK Germany2
Hazard Codes T,N T,N,F F,T
Hazard statements
  • H370 Causes damage to organs 导致器官损伤
  • H331 Toxic if inhaled 吸入中毒
  • H311 Toxic in contact with skin 皮肤接触中毒
  • H301 Toxic if swallowed 吞食有毒
  • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
  • H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
  • H351 Suspected of causing cancer 怀疑致癌
  • H341 Suspected of causing genetic defects 怀疑导致遗传性缺陷
  • H318 Causes serious eye damage 严重伤害眼睛
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H372 Causes damage to organs through prolonged or repeated exposure 长期或频繁接触会损伤器官
  • H227 Combustible liquid 可燃液体
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSBW6650000
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P301+P310
  • P302+P350
  • P305+P351+P338
  • P304+P340
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P304+P340+P310
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P370+P378
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P403+P233
Signal word
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S27 Take off immediately all contaminated clothing 立即脱掉全部污染的衣服;
  • S63
  • S46 If swallowed, seek medical advice immediately and show this container or label 食入时,立即求医并出示容器/标签;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中,参考特别指示/安全收据说明书;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
Risk Statements
UN Number
Packing GroupII
Storage condition 充氩保存 储存温度2-8℃ 密封阴凉干燥避光保存。 玻璃安瓿瓶包装,冷藏保存。 密封阴凉干燥保存。 玻璃安瓿瓶包装,冷藏和避光条件下保存。 2-8°C
Hazard Class6.1
Warnings 危化品目录(2015)
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 11 gm/kg/29W-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Kidney, Ureter, Bladder - tumors
REFERENCE :
   APMIAL Acta Pathologica et Microbiologica Scandinavica.  (Copenhagen,
   Denmark)  V.1-77, 1924-69.  For publisher information, see ACPADQ.
   Volume(issue)/page/year: 26,472,1949

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 72800 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Blood - tumors
REFERENCE :
   FCTOD7 Food and Chemical Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.20-    1982- Volume(issue)/page/year:
   25,619,1987

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 464 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 13(5),29,1969

TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 250 ppm/4H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JIHTAB Journal of Industrial Hygiene and Toxicology.  (Cambridge, MA)
   V.18-31, 1936-49.  For publisher information, see AEHLAU.
   Volume(issue)/page/year: 31,343,1949

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 90,260,1947

T

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig,
   Ger. Dem. Rep.)  Volume(issue)/page/year: 4,1301,1935

TYPE OF TEST            : LD50 - Lethal d

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 100 ug/plate
REFERENCE :
   PJABDW Proceedings of the Japan Academy, Series B: Physical and Biological
   Sciences.  (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31,
   Japan)  V.53-    1977-  Volume(issue)/page/year: 53,34,1977

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 39658 ug/well/16H
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Volume(issue)/page/year:
   15,219,1976

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 50 mg/kg
REFERENCE :
   JPMSAE Journal of Pharmaceutical Sciences.  (American Pharmaceutical Assoc.,
   2215 Constitution Ave., NW, Washington, DC 20037)  V.50-    1961-
   Volume(issue)/page/year: 80,761,1991

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 500 umol/L
REFERENCE :
   MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
   Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-  Volume(issue)/page/year: 3,193,1988

TYPE OF TEST            : Specific locus test
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 500 mg/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Li

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 200 umol/L
REFERENCE :
   TOLED5 Toxicology Letters.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1977-  Volume(issue)/page/year: 16,235,1983

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 4480 mg/kg
SEX/DURATION            : female 6-13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis.  (Alan R. Liss, Inc.,
   41 E. 11th St., New York, NY 10003)  V.1-    1980- Volume(issue)/page/year:
   7,29,1987

Restrict 危险品

其他信息

  • 灭火剂:泡沫、二氧化碳、干粉
  • 蒸气压:0.7 mm Hg ( 25 °C)
  • 存储注意事
  • 有特殊气味和灼烧味。露置空气与光线下色变深。能随水蒸气挥发。与酸反应形成盐,能溶解碱或碱土金属并放出氢生成苯胺化合物。能与乙醇、氯仿、苯和大多数有机溶剂混溶。1G溶于28.6ml水、15.7ml沸水。0.2mol水溶液pH为8.1。
  • 图谱信息:氨基苯(62-53-3)红外图谱(IR1) 氨基苯(62-53-3)质谱(MS) 氨基苯(62-53-3)核磁图( 13 CNMR) 氨基苯(62-53-3)核磁图( 1 HNMR) 氨基苯(62-53-3)红外图谱(IR2)
  • 外观性质:无色或微黄色油状液体,有强烈气味。
  • 刺激数据:皮肤- 兔子 20 毫克/
  • 用途三:苯胺是生产农药的重要原料,由苯胺可衍生N-烷基苯胺、烷基苯胺、邻硝基苯胺、邻苯二胺、苯肼、环己胺等,可作为杀菌剂敌锈钠、拌种灵、甲基灭菌胺、灭菌胺、多菌灵、嘧菌灵、苯菌灵,杀虫剂三唑磷、哒嗪硫磷、喹硫磷,除草剂甲草胺、乙草胺、丁草胺、环嗪酮、咪唑喹啉酸等的中间体。
  • 上游原料:硝酸 --> 苯 --> 氮 --> 氢 --> 硝基苯 --> 氧化铁
  • 爆炸物危险特性:与空气混合可爆; 与氧化剂反应剧烈
  • 可燃性危险特性:明火、高温、强氧化剂可燃; 高热分解有毒氮氧化物气体
  • 下游产品:8-苯胺-1-萘磺酸 --> 直接橙 S --> 2-[[3-[[(2,3-二氢-2-氧代-1H-苯并咪唑-5-基)氨基]甲酰]-2-羟基-1-萘]偶氮]苯甲酸丁酯 --> 2,2,4-三甲基-1,2-二氢喹啉聚合物 --> 颜料红 175 --> 3-溴-2-吡啶羧酸 --> 荧光增白剂 --> N,N-二氰乙基苯胺 --> 4-癸基苯胺 --> 4-溴-2-三氟甲基喹啉 --> 金光红 --> 盐酸苯胺 --> 活性兰222 --> 活性紫5 --> 溶解盐SV --> 十二氢二苯胺 --> 2-氯马来醛 --> N-苯基吡啶-4-酰胺 --> 酸性黄79 --> 酸性黑26 --> 利达脒 --> 碱性橙 --> 1-萘氨基苯 --> 2-(三氟甲基)喹啉-4-醇 --> 油黑 --> 分散大红S-3GFL --> 双苯基脲 --> N-苯基-2-
  • 职业标准:TLV-TWA 2 PPM; TWA 5 PPM (19 毫克/ 立方米); STEL 20 毫克/ 立方米
  • 国内生产工艺路线研究:在我国近年对苯与H2O2反应制苯胺的研究比较多。2003年,厦门市先端科技有限公司开发了由苯、氨和氧直接合成苯胺的工艺。此工艺具有苯转化率高、选择性好的特点。苯与质量分数为25%的氨水和氧在1.5MPa和140~160℃条件下合成苯胺,苯胺的总选择性为94%(另有大约5%的苯酚和1%的苯);如果由苯、液态氨和氧在2.0~8.1MPa和 160~200℃条件下合成苯胺,总选择性为95%。此工艺所用的催化剂是金属氧化物、金属氯化物、金属氟化物、金属碘化物、金属硫酸盐、金属磷酸盐、金属杂多酸盐、BF3、除铁粉外的金属,以及上列化合物的任意比例混合物,载体是至少有一种选自如SiO2、B2O3、Al2O3、GeO2、TiO2、ZrO2、Nb2O5、Ta2O5、活性炭等的金属化合物或非金属化合物。 四川大学化学学院与四川省绿色化学与技术重点实验室2004年采用H2O2作氧化剂,实现了由苯直接氧化胺化合成苯胺,并公开了制备方法的专利。研究人员开发出Ni-Zr-Ce/Al2O3催化剂,在常压、50℃的温和条件下,该催化剂对苯、氨水与H2O2直接氧化胺化生成苯胺有较好活性,生成苯胺的选择性远大于苯酚,提高反应原料中氨水对苯的比例,可提高苯胺的收率,且不会增加苯酚的生成量。本方法能耗低,原子利用率高,为苯胺的绿色合成提供了一条新的路径。一步合成苯胺的催化剂是以γ-Al2O3为载体,以镍、钼、钒、锰、锆、铈中的2种或3种作为催化剂活性组分,经浸渍、焙烧等处理而获得。在由苯直接氧化胺化一步合成苯胺中,该催化剂在较温和的反应条件下具有较高活性,选择性可达100%。
  • 用途四:苯胺是重要的中间体。由苯胺生产的较重要产品达300种。世界苯胺生产厂家大约有80多个,年总生产能力已超过270万t/a,产量

系列性分类