• 原料直供
• 试剂商城
• 直接询价

分类

• {SNA} Analytical Standards, EP Standards, EP Standards A - B, Pharmacopeia Metrological Institutes Standards, 分析/色谱
• {uni_hamburg} no charge; carbocycle; aromatic; 6RingOnly; 6ring; ester; 1fragment
• {SNA} Analytical/Chromatography,
• {SNA} Analytical Standards, Chromatography, EP Standards, EP Standards A - B, Pharmaceutical Standards, Pharmacopeia Standards, 分析/色谱
• B, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Core Bioreagents
• {SNA} Analytical Standards, EP Standards, EP Standards A - B, Pharmacopeia & Metrological Institutes Standards, 分析/色谱
• {SNA} Core Bioreagents, Enzyme Inhibitors, Ion Channels, Monovalent Ion Channels,
• {SNA} Building Blocks,

产品应用

• 该品为局部麻醉药，用于创面，溃疡面及痔疮的止痛，也是镇咳药退嗽的中间体。

相关文献及参考

• Merck 14 ,1086
• Ayehunie, S., et al., Development Of An In Vitro Alternative Assay Method For Vaginal Irritation. Toxicology 279 , 130-8, (2011) 摘要
• Kholod, Y., et al.: Environ. Sci. Technol., 43, 9208 (2009),
• Qiao, C., et al., Liver-specific MicroRNA-122 Target Sequences Incorporated In AAV Vectors Efficiently Inhibits Transgene Expression In The Liver. Gene Ther. 18 , 403-10, (2011) 摘要
• Gavrilov, V., et al., Influenza Virus-like Particles As A New Tool For Vaccine Immunogenicity Testing: Validation Of A Neuraminidase Neutralizing Antibody Assay. J. Virol. Meth. 173 , 364-73, (2011) 摘要
• Merck: 14,1086 Beilstein:14(3)1025
• Fliri, A., et al.: J. Med. Chem., 52, 8038 (2009),
• Perez-Garrido, Alfonso; Helguera, A., et al.: J. Pharm. Sci., 98, 4557 (2009),
• Merck: 14,1086
• Jászai, J., et al., Distinct And Conserved Prominin-1/CD133-Positive Retinal Cell Populations Identified Across Species. PLoS ONE 6 , e17590, (2011) 摘要
• Short: III/31a
• Quan, F.S., et al., Kinetics Of Immune Responses To Influenza Virus-like Particles And Dose-dependence Of Protection With A Single Vaccination. J. Virol. 83 , 4489-97, (2009) 摘要
• Ding, H., et al., Superior Neutralizing Antibody Response And Protection In Mice Vaccinated With Heterologous DNA Prime And Virus Like Particle Boost Against HPAI H5N1 Virus. PLoS ONE 6 , e16563, (2011) 摘要

安全信息

GHS Symbol

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Rectal
SPECIES OBSERVED        : Human - infant
DOSE/DURATION           : 12 mg/kg
TOXIC EFFECTS :
   Blood - methemoglobinemia-carboxyhemoglobin
REFERENCE :
   NEJMAG New England Journal of Medicine.  (Massachusetts Medical Soc., 10
   Shattuck St., Boston, MA 02115)  V.198-    1928-  Volume(issue)/page/year:
   263,454,1960

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - wild bird species
DOSE/DURATION           : 56 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   21,315,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2500 mg/kg
TOXIC EFFECTS :
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - dyspnea
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   TOVEFN Toksikologicheskii Vestnik.  (18-20 Vadkovskii per.  Moscow, 101479,
   Russia) History Unknown  Volume(issue)/page/year: (2),34,1996

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 216 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 17,900,1974

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其他信息

• 苯唑卡因价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 A0271 4-氨基苯甲酸乙酯 Ethyl 4-Aminobenzoate 500G 621元 2014/06/02 A0271 4-氨基苯甲酸乙酯 Ethyl 4-Aminobenzoate 25G 121元 2010/06/21 150781000 苯唑卡因 Ethyl 4-aminobenzoate 98% 100 GR 334元
• 脂溶性表面麻醉剂:苯唑卡因是一种脂溶性表面麻醉剂，与其它几种局麻药如利多卡因、地卡因等相比，其作用强度较小，因而在作用于粘膜时不会因麻醉作用而使人感到不适。它是一种脂溶性较强的药物，故而易与粘膜或皮肤的脂层结合，但不易透过而进人体内产生毒性。 苯唑卡因可作为奥索仿、奥索卡因、普鲁卡因等前体原料；同时，它在医药上又用作局部麻醉剂，有止痛、止痒作用，主要用于创面、溃疡面、粘膜表面和痔疮麻醉止痛和痒症，其软膏还可用作鼻咽导管、内突窥镜等润滑止痛。暂时缓解疼痛和瘙痒皮肤的不适，轻度烧伤、晒伤、创伤和昆虫叮咬。耳用制剂被用来减轻急性充血性、浓性外耳炎、游泳耳炎的疼痛和瘙痒以及耳外用。对牙痛、咽喉痛、口腔溃疡、各种痔疮、肛裂、外阴瘙痒也是有效的，作为男性生殖器脱敏剂使射精缓慢。或用作导管和内镜管的麻醉润滑剂。
• TCI Shanghai:4-氨基苯甲酸乙酯 Ethyl 4-Aminobenzoate,>;99.0%(GC)(T)(94-09-7)
• 外观性质:无色、无臭、无味的晶体。
• 图谱信息:苯唑卡因(94-09-7)核磁图( 13 CNMR) 苯唑卡因(94-09-7)质谱(MS) 苯唑卡因(94-09-7)红外图谱(IR3) 苯唑卡因(94-09-7)核磁图( 1 HNMR) 苯唑卡因(94-09-7)红外图谱(IR1) 苯唑卡因(94-09-7)Raman光谱 苯唑卡因(94-09-7)红外图谱(IR2)
• 上游原料:对氨基苯甲酸 --> 4-氨基邻苯二甲酸 --> 对硝基苯甲酸乙酯
• 毒害物质数据:94-09-7(Hazardous Substances Data)
• 1g该品溶于约2500ml水、5ml乙醇、2ml氯仿、4ml乙醚或30-50ml杏仁油及橄榄油，也溶于稀酸。在空气中稳定，无臭，味苦。
• EPA Substance Registry System:94-09-7(EPA Substance)
• Alfa Aesar:4-氨基苯甲酸乙酯,98% Ethyl 4-aminobenzoate, 98%(94-09-7)
• 用途一:用于化妆品紫外线吸收，局部麻醉药，用于创面、溃疡面及痔疮的止痛
• 海关编码:29224995
• 方法一:由对硝基苯甲酸乙酯[99-77-4]铁粉还原而得。
• MOL 文件:94-09-7.mol
• 用途二:该品为局部麻醉药，用于创面，溃疡面及痔疮的止痛，也是镇咳药退嗽的中间体。
• 下游产品:对氟苯甲酸 --> 苯佐那酯 --> 4-(正丁基氨基)苯甲酸乙酯
• 苯唑卡因价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/04/16 A0271 4-氨基苯甲酸乙酯 Ethyl 4-Aminobenzoate 500G 862元 2011/04/16 A0271 4-氨基苯甲酸乙酯 Ethyl 4-Aminobenzoate 25G 167元 2010/06/21 150781000 苯唑卡因 Ethyl 4-aminobenzoate 98% 100 GR 334元