Methyl Methacrylate 甲基丙烯酸甲酯

CAS 80-62-6 MFCD00008587

化学结构图

80-62-6
SMILES: C=C(C)C(=O)OC

化学属性

Mol. FormulaC₅H₈O₂
Mol. Weight100.12
Refractive index1.4130 to 1.4160
Boiling Point-
Density0.93
Melting Point-48
Flash Point-
TSCAYes
Autoignition Point815 °F
Vapor Density3.5 (vs air)
Vapor Pressure29 mmHg ( 20 °C)
SolubilitySoluble in water (15 mg/ml).
Stability对热和光线敏感
Danger-Level甲类

别名和识别编码

Chemical NameMethyl Methacrylate
CAS Number80-62-6
PubChem Substance ID6658
EC Number201-297-1
Beilstein Registry Number605459
MDL Number-
Reaxys-RN605459
Merck Number5941
Synonym 2-(methoxycarbonyl)-1-propene 2-Met 2-Methyl-2-propensäuremethylester 2-Methylpropenoic acid methyl ester 2-Methylpropenoicacidmethylester 2-methyl-acrylic acid methyl ester 2-methyl-acrylicacimethylester 2-methyl2-propenoicacid,methylester 2-甲基丙烯酸甲酯 METHACRYLIC ACID METH MMA MME Metakrylan metylu Meth Methacryl Methacrylic acid, methyl ester; Methyl 2-methylpropenoate. Methacrylsäure-methylester Methyl 2-methylacrylate Methyl Methacrylate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
Chemical Name Translation甲基丙烯酸甲酯
Wiswesser Line Notation1UY1&VO1
LabNetwork Molecule IDLN00192999
InChIInChI=1S/C5H8O2/c1-4(2)5(6)7-3/h1H2,2-3H3
Canonical SMILES-
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品牌质保精细包装    现货库存    一流品牌服务   

分类

  • {SNA} Alphabetical Listings, Flavors and Fragrances, M-N
  • {SNA} Analytical Reagents, Analytical/Chromatography, Building Blocks, C2 to C5, Carbonyl Compounds, Chemical Synthesis, Embedding Media,
  • {uni_hamburg} no charge; ester; 1fragment
  • {Chemicalbook} 农药中间体: 杀菌剂中间体: 酰胺类杀菌剂
  • {SNA} Acrylic Monomers, Building Blocks, C2 to C5, Carbonyl Compounds, Chemical Synthesis, Esters, Low Refractive Index Monomers, Methacrylate, Monomers, Organic Building Blocks, Organic and Printed Electronics, Photonic and Optical Materials, Polymer Science, Waveguide Materials, 材料科学

产品应用

  • 有机合成。

相关文献及参考

  • Short: II/27B
  • Merck: 14,5941
  • Merck: 14,5941 Beilstein:2(2)398
  • Short: II/2

安全信息

GHS Symbol
WGK Germany1
Hazard Codes 3 F,Xi,T F;Xi
Hazard statements
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
  • H315 Causes skin irritation 会刺激皮肤
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSOZ5075000
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P233 Keep container tightly closed. ?保持容器密闭。
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P241+P242+P243
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P302+P352
  • P302+P352+P333+P313+P362+P364
  • P303+P361+P353
  • P304+P340
  • P304+P340+P312
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P308+P313
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P337+P313
  • P370+P378
  • P403+P233
  • P403+P235
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
Safety Statements
  • S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
  • S24 Avoid contact with skin 避免皮肤接触；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S37 Wear suitable gloves 戴适当手套；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S46 If swallowed, seek medical advice immediately and show this container or label 食入时，立即求医并出示容器/标签；
  • S7 Keep container tightly closed 保存在严格密闭容器中；
Risk Statements
  • R11 Highly flammable 非常易燃
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R37/38 Irritating to respiratory system and skin 对呼吸系统和皮肤有刺激性
  • R39/23/24/25 Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed 毒性：吸入，皮肤接触和吞食都会产生十分严重的不可逆危险
  • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
  • R52 Harmful to aquatic organisms 对水生生物有害
UN Number 1247
Storage condition 0-10 0-10°C 4 4°C Refrigerator 储存温度2-8℃
Packing GroupII
Hazard Class3
Warnings 危化品目录(2015) 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Implant
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1620 mg/kg
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   CORTBR Clinical Orthopaedics and Related Research.  (Lippincott/Harper,
   Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) No.26- 
     1963-  Volume(issue)/page/year: 88,223,1972

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Human
DOSE/DURATION           : 125 ppm
TOXIC EFFECTS :
   Behavioral - sleep
   Behavioral - excitement
   Behavioral - anorexia (human)
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 19(10),25,1954

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 120 uL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPMSAE Journal of Pharmaceutical Sciences.  (American Pharmaceutical Assoc.,
   2215 Constitution Ave., NW, Washington, DC 20037)  V.50-    1961-
   Volume(issue)/page/year: 63,376,1974

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 7 mL/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Kidney, Ureter, Bladder - changes primarily in glomeruli
   Biochemical - Metabolism (Intermediary) - porphyrin including bile pigments
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: OTS0520933

TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 19000 mg/m3/5H
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Behavioral - coma
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   JIHTAB Journal of Industria

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 34 mmol/L
REFERENCE :
   JBJSA3 Journal of Bone and Joint Surgery, American Volume.  (10 Shattuck
   St., Boston, MA 02115) V.30-    1948-  Volume(issue)/page/year:
   61A,1203,1979

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 500 mg/L
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 8(Suppl
   6),4,1986

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 2799 mg/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)

TYPE OF TEST            : Micronucleus test
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 2202 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 222,191,1989

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 1500 mg/L
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-314,1986

TYPE OF TEST            : Mutation in mammal

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 2202 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 222,191,1989

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Human - woman
DOSE                    : 10 mg/m3
SEX/DURATION            : female 9 year(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - other effects
   Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
   (e.g., placenta, umbilical cord)
   Reproductive - Effects on Newborn - delayed effects
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 62(4),19,1997

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intrape

TYPE OF TES

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 801 mg/kg
SEX/DURATION            : female 5-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - other developmental
   abnormalities
REFERENCE :
   JDREAF Journal of Dental Research.  (International Assoc. for Dental
   Research, 734 15th St., NW, Suite 809, Washington, DC 20005)  V.1-    1919-
   Volume(issue

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 54 mg/m3/24H
SEX/DURATION            : female 8 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 21(2),49,1977

Restrict 危险品

其他信息

  • 蒸气密度:3.5 (vs air)
  • FEMA:4002
  • 下游产品:卡波姆树脂 --> 2,2-二氯-1-甲基环丙胺 --> 苯丙乳液 --> 氯丁胶 --> 4-氯-7-甲基噻吩并[3,2-D]嘧啶 --> 1-苄基-3-甲基-4-哌啶酮 --> 导电涂料-丙烯酸酯共聚物和碘化亚铜复合体系 --> CC-2SH胶粘剂前牙复合树脂 --> 微粒丙烯酸树脂填充乳液 --> GD可见光固化复合树脂 --> 光盘基材用改性聚甲基丙烯酸甲酯共聚树脂 --> 腐霉利 --> 网印印花粘合剂 --> 2-甲基-2-丙烯酸-2,3-二羟基丙酯 --> AVERGE MW~350000 BY GPC .TG(DSC)122 --> 5-甲基脲嘧啶 --> 羧基型阳离子交换树脂 --> 3-氨基-4-甲基噻吩-2-甲酸甲酯 --> 压敏胶 --> 皮革光亮剂 --> 热塑性丙烯酸树脂 --> 比卡鲁胺 --> 3-(甲基丙烯酰氧)丙基三甲氧基硅烷 --> 增稠剂 PAE --> 二氢朐腺嘧啶
  • TCI Shanghai:甲基丙烯酸甲酯(含稳定剂6-叔丁基-2,4-二甲苯酚) Methyl Methacrylate (stabilized with 6-tert-Butyl-2,4-xylenol),>;99.8%(GC)(80-62-6)
  • 防护措施:毒性较小。大鼠经口LD50为9400mg/kg。吸入致死浓度LC50为15.33g/m3。作业最高容许浓度为410mg/m3。但其嗅阈为130～250mg/m3，当其浓度尚未达产生毒性之前，其强烈臭味已使人难忍。人体皮肤接触甲基丙烯酸甲酯，只有极少数人会出现红疹。 由于生产甲基丙烯酸甲酯的原料氰化钠和中间体氰化氢剧毒，生产装置必须严格保证设备密闭，并保持良好通风，操作人员应有严格的防护措施，配备必要的防护装具。发现中毒现象应立即移至空气新鲜处及时抢救。
  • 方法一:其制备方法有以下几种。 (1)丙酮氰醇法 丙酮与氰化氢反应生成丙酮氰醇，丙酮氰醇与硫酸及甲醇反应，制得甲基丙烯酸甲酯，得到的粗酯经盐析、初馏、精馏得产品。 (2)丙烯法 丙烯、一氧化碳与甲醇反应，合成中间体2-甲氧基-2-甲基丙酸甲酯，将它分解生成甲基丙烯酸甲酯和甲醇。 (3)异丁烯法 将异丁烯用氧化剂在K 2 CO 3 或MnO 2 催化剂存在下氧化成甲基丙烯酸或用空气在钼催化剂存在下分两段氧化，即先氧化成甲基丙烯醛，进一步氧化成甲基丙烯酸，它再
  • 检测方法:GC
  • 方法二:1.丙酮氰醇路线丙酮氰醇与硫酸反应生成甲基丙烯酰胺硫酸盐，经水解后再与甲醇酯化得甲基丙烯酸甲酯粗制品，然后经盐析、粗馏、精馏得成品。通常丙酮氰醇由氰化钠制得原料消耗定额：甲酮氰醇1100kg/t、硫酸2100kg/t、甲醇490kg/t。2.异丁烯路线异丁烯在钼催化剂存在下用空气两段氧化。异丁烯先氧化成甲基丙烯醛，再进一步氧化成甲基丙烯酸。甲基丙烯酸与甲醇酯化得甲基丙烯酸甲酯。最近，又开发出一步氧化法工艺。异丁烯以N2O4为氧化剂，K2CO3或MnO2为催化剂，直接氧化生成甲基丙烯酸。然后再用甲醇酯化。3.丙烯路线丙烯、一氧化碳与甲醇进行羰化反应生成2-甲氧基异丁酸甲酯，然后通过水解反应分解成甲基丙烯酸甲酯和甲醇。4.异丁醛一步氧化法以杂多酸及其盐类为催化剂，由异丁醛一步氧化生成甲基丙烯酸，甲基丙烯酸再与甲醇酯化成甲基丙烯酸甲酯。
  • 用途三:该品主要用作聚甲基丙烯酸甲酯（有机玻璃）的单体，也与其他乙烯基单体共聚得到不同性质的产品，也用于制造其他树脂、塑料、粘合剂、涂料、润滑剂、木材浸润剂、电机线圈浸透剂、离子交换树脂、纸张上光剂、
  • 毒性分级:中毒
  • 用途一:主要用作有机玻璃的单体，也用于制其他塑料、涂料等
  • 图谱信息:甲基丙烯酸甲酯(80-62-6)Raman光谱 甲基丙烯酸甲酯(80-62-6)红外图谱(IR1) 甲基丙烯酸甲酯(80-62-6)质谱(MS) 甲基丙烯酸甲酯(80-62-6)核磁图( 1 HNMR) 甲基丙烯酸甲酯(80-62-6)核磁图( 13 CNMR)
  • 用途二:甲基丙烯酸甲酯是杀菌剂菌核净的中间体。
  • 类别:易燃液体
  • 可燃性危险特性:遇明火、高温、氧化剂易燃; 燃烧产生刺激烟雾

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Esters - Carbonyl Compounds
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. M - Alphabetic
  5. META - METH - M
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Esters - Carbonyl Compounds
  6. C2 to C5 - Esters
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Esters
  6. C12 to C63
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Monomers
  4. Acrylic Monomers 丙烯酸单体
  5. Fluorinated Acrylics