Methylhydrazine sulfate 甲基肼硫酸盐

CAS 302-15-8 MFCD00035423

化学结构图

302-15-8
SMILES: CNN.O=S(=O)(O)O

化学属性

Mol. FormulaCH8N2O4S
Mol. Weight144.15
Melting Point143°C
TSCAYes
Appearance 甲基肼硫酸盐(302-15-8)为甲基肼的硫酸盐。甲基肼为澄明液体,沸点 87.5℃,呈强还原性,与强氧化剂接触易燃烧,闪点 70℃,对皮肤及黏膜有强刺激性,并显示很强的生理毒性;甲基肼硫酸盐为白色片状结晶,熔点 141-142℃,使用比较安全。

别名和识别编码

Chemical NameMethylhydrazine sulfate
CAS Number302-15-8
Synonym Methylhydrazine sulfate {LY} Methylhydrazine sulfate {} {LY} Methylhydrazine sulfate {} {} {LY} Methylhydrazine sulfate {} {} {} {LY} Methylhydrazine sulfate {} {} {} {} {LY} Methylhydrazine sulfate {} {} {} {} {} {LY} Methylhydrazine sulfate {} {} {} {} {} {} {LY} Methylhydrazine sulfate {} {} {} {} {} {} {} {LY} Methylhydrazine sulfate {} {} {} {} {} {} {} {} {LY} Methylhydrazine sulfate {} {} {} {} {} {} {} {} {} {LY} Methylhydrazine sulfate {} {} {} {} {} {} {} {} {} {} {LY} Methylhydrazine sulfate {} {} {} {} {} {} {} {} {} {} {} {LY} Methylhydrazine sulfate {} {} {} {} {} {} {} {} {} {} {} {} {LY} Methylhydrazine sulfate {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Methylhydrazine sulfate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Methylhydrazine sulfate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Methylhydrazine sulfate {} {} {} {} {} {} {} {} {} {} {} {} {}
MDL NumberMFCD00035423
EC Number206-115-4
Merck Number14,6086
Beilstein Registry Number3693575
Reaxys-RN3693575
PubChem Substance ID165286
Chemical Name Translation甲基肼硫酸盐
Wiswesser Line NotationZM1 &WSQQ
LabNetwork Molecule IDLN00221312
InChIInChI=1S/CH6N2.H2O4S/c1-3-2;1-5(2,3)4/h3H,2H2,1H3;(H2,1,2,3,4)
Canonical SMILESO=S(O)(O)=O.CNN
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分类

  • Amines
  • Sulfur & Selenium Compounds

产品应用

  • A substituted hydrazine used in the preparation of pyrazole-3-carboxamide derivatives as 5-HT2B receptor antagonists.

相关文献及参考

  • Evans, B., et al.: J. Med. Chem., 31, 2235 (1988),
  • Schreiber, S., et al.: Bioorg. Med. Chem., 6, 1127 (1998),

安全信息

RTECSMV7750000
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S27 Take off immediately all contaminated clothing 立即脱掉全部污染的衣服;
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
Packing GroupIII
UN Number 2811
Risk Statements
  • R000923/24/25
  • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
Signal word
Hazard statements
  • H301+H311+H331
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P310+P330
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P403+P233
  • P302+P352+P312+P361+P364
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P405 Store locked up. 上锁保管。
  • P304+P340+P311
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P302+P350
  • P301+P310
  • P361 Remove/Take off immediately all contaminated clothing. 立即去除/脱掉所有被污染的衣服。
  • P302+P352
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
Hazard Class6.1
GHS Symbol
Hazard Codes
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2092 mg/kg/83W-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Blood - lymphoma, including Hodgkin's disease
REFERENCE :
   IJCNAW International Journal of Cancer.  (International Union Against
   Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland)  V.1-    1966-
   Volume(issue)/page/year: 9,109,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 160 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RPTOAN Russian Pharmacology and Toxicology (English Translation).
   Translation of FATOAO.  (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey,
   UK)  V.30-    1967-  Volume(issue)/page/year: 36,27,1973

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Rodent - mouse Liver
DOSE/DURATION           : 100 umol/L
REFERENCE :
   JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB
   211, 1000 AE Amsterdam, Netherlands)  V.76-    1985-
   Volume(issue)/page/year: 79,204,1988

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 10 umol/L
REFERENCE :
   JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB
   211, 1000 AE Amsterdam, Netherlands)  V.76-    1985-
   Volume(issue)/page/year: 79,204,1988

Storage condition 2-8°C, stored under nitrogen {LY} 2-8°C, stored under nitrogen Store at room temperature {} {LY} 2-8°C, stored under nitrogen {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°

其他信息

  • 方法一:用肼与苯甲醛缩合,生成苄叉连氮,后都与硫酸二甲酯在苯中回流反应得到该品。
  • 上游原料:苄连氮
  • MOL 文件:302-15-8.mol
  • Sigma Aldrich:302-15-8(sigmaaldrich)
  • Alfa Aesar:甲基硫酸肼,98% Methylhydrazine sulfate, 98%(302-15-8)
  • 甲基肼硫酸盐价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 M0341 硫酸甲肼 Methylhydrazine Sulfate 25G 1120元 2010/05/25 L10122 甲基硫酸肼, 98% Methylhydrazine sulfate, 98% 5g 493元 2010/05/25 L10122 甲基硫酸肼, 98% Methylhydrazine sulfate, 98% 25g 1764元
  • 下游产品:甲基肼 --> 5-氨基-1,3-二甲基吡唑 --> (6R,7R)-7-[[(2E)-2-(2-氨基-1,3-噻唑-4-基)-2-甲氧基亚氨乙酰]氨基]-3-[(2-甲基-5,6-二氧代-1H-1,2,4-三嗪-3-基)硫甲基]-8-氧代-5-硫-1-氮杂双环[4.2.0]辛-2-烯-2-甲酸 --> 4-氯-1,3-二甲基-1H-吡唑3,4-吡啶-5-羧酸 --> 二甲基异唑四异氰酸酯 --> 1-甲基-5-三氟甲基-4-溴-1H-吡唑 --> 4-氯-1,3-二甲基吡唑并[3,4-B]吡啶-5-羰酰氯 --> 1,3-二甲基-4-氯-1H-吡唑[3,4-B]并吡啶-5-甲酸乙酯
  • 用途一:甲基苄肼(异丙胺酰苄肼)的中间体。甲基肼为火箭燃料。
  • TCI Shanghai:硫酸甲肼 Methylhydrazine Sulfate,>;98.0%(T)(302-15-8)
  • 图谱信息:甲基肼硫酸盐(302-15-8)红外图谱(IR1) 甲基肼硫酸盐(302-15-8)核磁图( 1 HNMR) 甲基肼硫酸盐(302-15-8)核磁图( 13 CNMR)
  • MSDS 信息:Methylhydrazine sulfate (302-15-8).msds

系列性分类