Maleic Acid 顺丁烯二酸

CAS 110-16-7 MFCD00063177

化学结构图

110-16-7
SMILES: O=C(O)C=CC(=O)O

化学属性

Mol. FormulaC4H4O4
Mol. Weight116.07
Density1.59
Melting Point130-135 °C
Flash Point127°C
TSCAYes
Solubility溶于水,溶于乙醇、丙酮,微溶于苯。
Boiling Point275 °C at 760 mmHg
Stability对湿度敏感

别名和识别编码

Chemical NameMaleic Acid
CAS Number110-16-7
EC Number203-742-5
Beilstein Registry Number605762
MDL NumberMFCD00063177
Synonym Maleic Acid {LY} Maleic Acid {} {LY} Maleic Acid {} {} {LY} Maleic Acid {} {} {} {LY} Maleic Acid {} {} {} {} {} {} {} {} {LY} Maleic Acid {} {} {} {} {} {LY} Maleic Acid {} {} {} {} {} {} {LY} Maleic Acid {} {} {} {} {} {} {} {LY} Maleic Acid {} {} {} {} {} {} {} {} {LY} Maleic Acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Maleic Acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Maleic Acid {} {} {} {} {} {} {} {} {} {} {} {LY} Maleic Acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Maleic Acid {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Maleic Acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Maleic Acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Maleic Acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Maleic Acid
PubChem Substance ID444266
Merck Number5703
Chemical Name Translation顺丁烯二酸
Reaxys-RN605762
Wiswesser Line NotationQV1U1VQ -C
LabNetwork Molecule IDLN00238196
InChIInChI=1S/C4H4O4/c5-3(6)1-2-4(7)8/h1-2H,(H,5,6)(H,7,8)/b2-1-
Canonical SMILESO=C(O)/C=C\C(O)=O
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分类

  • {SNA} Biological Buffers, Buffers A to Z, Core Bioreagents, General Reagents, Life Science Reagents for RNAi,
  • {SNA} Analytical S
  • {S
  • {SNA} Analytical/Chromatography,
  • {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, EP Standards, EP Standards L - M, Pharmaceutical Standards, Pharmacopeia Standards
  • {SNA} Acids, Acids & Bases, Buffers A to Z, Chemical Synthesis, Core Bioreagents, General Reagents, Life Science Reagents for RNAi, Organic Acids, Panax ginseng, Phytochemicals by Plant (Food/Spice/Herb), Research Essentials, Synthetic Reagents, 生化试剂,

产品应用

  • 碱量法分析标准,减缓油及脂肪的酸败,有机合成。

相关文献及参考

  • Short: II/27B
  • Merck:14,5703 Beilstein:2,748
  • Merck:14,5703
  • Short: III/20a

安全信息

Signal word Danger Warning
GHS Symbol
WGK Germany1
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后,立即用大量…(由生产厂家指定)冲洗;
  • S37 Wear suitable gloves 戴适当手套;
Risk Statements
  • R21/22 Harmful in contact with skin and if swallowed 皮肤接触和不慎吞咽有害
  • R22 Harmful if swallowed 吞咽有害
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R37/38 Irritating to respiratory system and skin 对呼吸系统和皮肤有刺激性
  • R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
  • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
Precautionary statements
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312+P330
  • P301+P330+P331
  • P303+P361+P353
  • P304+P340
  • P305+P351+P338
  • P333+P313
  • P337+P313
  • P390 Absorb spillage to prevent material damage. 吸收溢出物,防止重大损害。
  • P403+P233
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H318 Causes serious eye damage 严重伤害眼睛
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H302+H312
  • H290 May be corrosive to metals 可能腐蚀金属。
  • H302 Harmful if swallowed 吞食有害
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves dust mask type N95 (US), Eyeshields, Faceshields, Gloves
RTECSOM9625000
Hazard Codes 9
UN Number 2215 3077
Packing GroupIII
Hazard Class8
Storage condition 2-8°C {LY} 2-8°C Store at RT. {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1560 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
REFERENCE :
   BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets.  (1810
   Frontage Rd., Northbrook, IL 60062)  Volume(issue)/page/year: 7-4/1970

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >720 mg/m3/1H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets.  (1810
   Frontage Rd., Northbrook, IL 60062)  Volume(issue)/page/year: 7-4/1970

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 708 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - muscle weakness
   Gastrointestinal - ulceration or bleeding from stomach
REFERENCE :
   BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets.  (1810
   Frontage Rd., Northbrook, IL 60062)  Volume(issue)/page/year: 7-4/1970

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2400 mg/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   BIJOAK Biochemical Journal.  (Biochemical Soc. Book Depot, POB 32, Commerce
   Way, Colchester, Essex CO2 8HP, UK)  V.1-    1906- Volume(issue)/page/year:
   34,1196,1940

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Fibroblast
DOSE/DURATION           : 20 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 183,89,1987

其他信息

  • Alfa Aesar:马来酸,98+% Maleic acid, 98+%(110-16-7)
  • 用途二:用于制备不饱和树脂和松香脂等
  • Sigma Aldrich:110-16-7(sigmaaldrich)
  • TCI Shanghai:顺丁烯二酸 Maleic Acid,>;99.0%(T)(110-16-7)
  • MSDS 信息:马来酸(110-16-7).msds
  • 马来酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 LA1459603 顺丁烯二酸 5kg 1002元 2011/08/23 30111328 顺丁烯二酸 500g 32.2元 2011/04/16 M0006 顺丁烯二酸 Maleic Acid 25G 177元
  • 方法一:1.苯氧化法纯苯经预热后,在钒系列催化剂作用下,经空气氧化生成顺丁烯二酸酐(以下简称顺酐),反应温度为360℃,然后经水吸收、浓缩、结晶和干燥得顺酸产品。2.丁烯(烷)氧化法丁烯(烷)在钒系催化剂作用下,经空气氧化生成顺酐,反应温度350-450℃,然后经水吸收生成顺酸,再经浓缩、干燥得成品。3.其他生产方法(1)萘或邻二甲苯氧化生成苯酐时副产顺酸;(2)糠醛氧化法,此法因效益问题不被采用。
  • 用途四:碱量法分析标准,减缓油及脂肪的酸败,有机合成。
  • 约在138℃时分解。溶于冰乙酸、乙醇、丙酮,微溶于乙醚和苯。实际上不溶于四氯化碳,有恶劣的酸气味,味涩。有腐蚀性。水中溶解度:790 g/L (25°C)。
  • 图谱信息:马来酸(110-16-7)质谱(MS) 马来酸(110-16-7)核磁图( 13 CNMR) 马来酸(110-16-7)核磁图( 1 HNMR) 马来酸(110-16-7)红外图谱(IR1)
  • 用途三:主要用于生产农药马拉松、达净松,合成不饱和聚酯树脂、酒石酸、反丁烯二酸、琥珀酸等产品,也用于涂料、食品和印染助剂及渍脂防腐剂等。
  • 上游原料:苯 --> 马来酸酐 --> 1,2-二甲苯 --> 2-糠醛
  • MOL 文件:110-16-7.mol
  • Acros Organics:顺丁烯二酸/马来酸 Maleic acid, 99%(110-16-7)
  • 下游产品:富马酸 --> L-天门冬氨酸 --> 丁二酸 --> D-酒石酸 --> 依那普利 --> DL-酒石酸 --> 富马酸二甲酯 --> 马拉硫磷 --> 伊索拉定 --> PBTCA类缓蚀剂 --> DL-天门冬氨酸 --> 克菌丹 --> 聚马来酸 --> 2-膦酸丁烷-1,2,4-三羧酸 --> 马来酸-烯丙醇共聚物 --> 氨氯地平 --> 氟吡汀 --> 马来酸二丁酯 --> 马来酸氯苯那敏 --> DL-苹果酸 --> 反丁烯二腈 --> 1,1'-二膦酸丙酸基膦酸钠 --> 3,4,5-三甲氧基苯甲酸 (2-二甲胺基-2-苯基)丁酯马来酸盐 --> DL-苹果酸 --> 5-溴-2-甲氧基肉桂酸 --> 巯基丁二酸 --> 泊拉得可
  • 外观性质:无色晶体, 有特臭。
  • 用途一:用于制药、树脂合成,也用作油和油脂的防腐剂

系列性分类