D-Penicillamine D-青霉胺
CAS 52-67-5 MFCD00064302
化学结构图
SMILES: CC(C)(S)[C@@H](N)C(=O)O
化学属性
| Mol. Formula | C5H11NO2S |
|---|---|
| Mol. Weight | 149 |
| Density | 1.204 |
| Melting Point | 210 |
| TSCA | No |
| Solubility | 11.1 G/100 ML (20 ºC) |
| Appearance | 白色细晶粉末。熔点198.5℃。易溶于水，微溶于乙醇，不溶于乙醚或氯仿。有特殊臭味，味苦。 |
| Refractive index | -63 ° (C=1, 1mol/L NaOH) |
别名和识别编码
| Chemical Name | D-Penicillamine |
|---|---|
| CAS Number | 52-67-5 |
| Synonym | (S)-3,3-Dimethylcysteine 3,3-二甲基-D-半胱氨酸 3,3-二甲基-D-半胱氨酸 3-巯基-D-缬氨酸 D-(-)-2-氨基-3-巯基-3-甲基丁酸 3-Mercapto-D-valine 3-mercapto-d-valin 3-巯基-D-缬氨酸 Cuprenil Cuprimine D-(-)-2-氨基-3-巯基-3-甲基丁酸 D-(-)-PENICILLAMINE D-(-)-青霉胺, 99% D-,-Dimethylcysteine, D--Mercaptovaline D-3-Mercaptovaline D-BETA-MERCAPTOVALINE D-PENICILLAMINE D-Penicillamine D-Valine, 3-mercapto- D-β,β-Dime D-β,β-Dimethylcysteine, D-β-Mercaptovaline D[-]-2-AMINO-3-MERCAPTO-3-METHYLBUTANOIC ACID Depamine Depen Reduced D-penicillamine Reduced penicillamine alpha-amino-beta-methyl-beta-mercaptobutyricacid β-巯基缬氨酸 青霉胺, 3,3-二甲基-D(-)-半胱胺酸 |
| EC Number | 200-148-8 |
| Beilstein Registry Number | 1722375 |
| MDL Number | MFCD00064302 |
| PubChem Substance ID | 5852 |
| Merck Number | 7088 |
| Chemical Name Translation | D-青霉胺 |
| Reaxys-RN | 1722375 |
| Wiswesser Line Notation | SHX1&1&YZVQ -D |
| LabNetwork Molecule ID | LN00239173 |
| InChI | InChI=1S/C5H11NO2S/c1-5(2,9)3(6)4(7)8/h3,9H,6H2,1-2H3,(H,7,8)/t3-/m0/s1 |
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资金保障
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信息真实价格透明
资金保障
专业采购外包团队在线服务
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现货库存
一流品牌服务
分类
- Amino Acids & Derivatives
- {SNA} Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics N-S, Bioactive Small Molecules, Cell Bio
- {SNA} Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics N-S, Biochemicals and Reagents, Chemical Biology, Chemical Structure Class, Chemical Synthesis, Interferes with Cell Wall Synthesis, L - Z, Mechanism of Action, PA-PH, Penicillamine Derivatives, Penicillins and Cephalosporins (beta-Lactams), Peptide Chemistry, Spectrum of Activity, Unnatural Amino Acid Derivatives, 生物活性小分子, 细
产品应用
- A Penicillin metabolite used in the treatment of Wilson?s disease, Cystinuria, Scleroderma and arsenic poisoning.
相关文献及参考
- Merck: 14,7088
- Merck: 14,7088 Beilstein: 4,IV,3228
- Marti-Prats, L., et al.: Neurosci. Lett., 483, 143 (2010),
- Singh, A., et al.: J. Pharm. Sci., 99, 3931 (2010),
- Everette, J., et al.: J. Agric. Food Chem., 58, 8139 (2010),
安全信息
GHS Symbol
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- S37 Wear suitable gloves 戴适当手套；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P302+P350
- P305+P351+P338
- P305+P351+P338+P337+P313
- P332+P313
- P337+P313
- P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- H361d Suspected of damaging the unborn child 怀疑对未出生婴儿造成伤害
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - child DOSE/DURATION : 122 gm/kg/3Y-C TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Blood - leukemia REFERENCE : JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 248,467,1982
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2 gm/kg/4W-I TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Blood - leukemia Blood - lymphoma, including Hodgkin's disease REFERENCE : LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 2,1356,1976
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human DOSE/DURATION : 21 mg/kg/D TOXIC EFFECTS : Kidney, Ureter, Bladder - proteinuria Blood - leukopenia Blood - thrombocytopenia REFERENCE : JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year: 240,1870,1978
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2080 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,758,1982
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 650 gm/kg/81W-I TOXIC EFFECTS : Behavioral - muscle weakness Musculoskeletal - other changes REFERENCE : ARHEAW Arthritis and Rheumatism. (Arthritis Foundation, 1314 Spring St., NW, Atlanta, GA 30309) V.1- 1958- Vol
TYPE OF TEST : TDLo - Lowest
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - child DOSE/DURATION : 40 mg/kg/1W-I TOXIC EFFECTS : Blood - leukopenia Skin and Appendages - dermatitis, other (after systemic exposure) Nutritional and Gross Metabolic - body temperature increase REFERENCE : AIMDAP Archives of Internal Medicine. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1908- Volume(issue)/page/year: 145,2271,1985
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneo
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 1 mg/plate REFERENCE : ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961- Volume(issue)/page/year: 45,2157,1981
TYPE OF TEST : Cytogenetic analysis TEST SYSTEM : Human Lymphocyte DOSE/DURATION : 2 gm/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 190,197,1987
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 20 umol/plate REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 224,89,1989
TYPE OF TEST : Cytogenetic analysis TEST SYSTEM : Rodent - hamster Lung DOSE/DURATION : 8 gm/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 190,197,1987
TYPE OF TEST : Sister chromatid exchange TEST SYSTEM : Human Lymphocyte DOSE/DURATION : 400 mg/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 190,197,1987
TYPE OF TEST : Sister chromatid exchange TEST SYSTEM : Rodent - hamster Lung DOSE/DURATION : 1 gm/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 190,197,1987
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 9130 mg/kg SEX/DURATION : female 1-22 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - other effects to embryo REFERENCE : TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 26,163,1982
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 1870 mg/kg SEX/DURATION : female 1-22 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - other neonatal measures or effects REFERENCE : TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 23,44A,1981
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE : 16 gm/kg SEX/DURATION : female 10-14 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) REFERENCE : TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 30,333,1984
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 1750 mg/kg
SEX/DURATION : female 17-22 day(s) after conception
lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproduc其他信息
- 方法一:由青霉素G钾盐水解而得。
- Sigma Aldrich:52-67-5(sigmaaldrich)
- 图谱信息: D-青霉胺(52-67-5)红外图谱(IR1) D-青霉胺(52-67-5)红外图谱(IR2) D-青霉胺(52-67-5)质谱(MS)
- MOL 文件:52-67-5.mol
- Alfa Aesar:D-(-)-青霉胺,99% D-(-)-Penicillamine, 99%(52-67-5)
- 用途二:该品为金属毒剂。其分子中的巯基和氨基能络合金属离子，生成水溶性络合物，从尿中排出。主要用于铜中毒，对铝、汞和锌等也有效，排铅不如EDTA钙，排汞不如BAL。该品可治疗某此免疫性疾病，如类风湿性关节炎、慢性活动性肝炎等。小鼠静脉注射LD50为2289mg/kg。
- Acros Organics:D(-)-青霉胺 D(-)-Penicillamine, 99+%(52-67-5)
- Hazard Note:Toxic
- 上游原料:青霉素钾
- MSDS 信息:3,3-Dimethyl-D(-)-cysteine(52-67-5).msds
- 水中溶剂的:11.1% ( 20 °C)，微溶于乙醇，不溶于乙醚、苯、丙酮和四氯化碳。
- TCI Shanghai:D-青霉胺 D-Penicillamine,>;98.0%(T)(52-67-5)
- 海关编码:29309016
- 比旋光度:-65 ° (c=5, 1M NaOH, on dry)
- 用途一:解毒药，用于重金属离子中毒，也用于类风湿性关节炎及慢性活动性肝炎等免疫性疾病
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