4-Nitrobenzoyl Chloride 4-硝基苯甲酰氯

CAS 122-04-3 MFCD00007345

化学结构图

122-04-3
SMILES: O=C(Cl)c1ccc([N+](=O)[O-])cc1

化学属性

Mol. FormulaC7H4ClNO3
Mol. Weight186
Density1.453
Boiling Point202-205
Melting Point71-74
Flash Point102°(215°F)
TSCAYes
Solubility分解
Stability易吸潮

别名和识别编码

Chemical Name4-Nitrobenzoyl Chloride
Synonym 4-硝基苯甲酰氯,氯化对硝基苯甲酰,硝酰 硝酰 4-Nitrobenzoic acid chloride 4-Nitrobenzoylchlorid 4-Nitro-benzoyl chloride 4-NITROBENZOIC ACID CHLORIDE p-Nitrobenzoyl chloride 4-nitro-benzoylchlorid p-Nitrobenzoic acid chloride 4-Nitrobenzoic acid chloran hydride Nitrobenzoyl chloride, 4- 4-Nitrobenzoyl Benzoyl chloride, p-nitro- Benzoyl chloride, 4-nitro- P-硝基苯甲酰氯 NITROBENZOYL-4 CHLORIDE 對硝苯甲醯氯 Benzoyl chloride, p-nitro- 4-硝基苯甲酰氯 p-Nitrobenzoic acid chloride Benzoylchloride,4-nitro- 4-NITROBENZOYL CHLORIDE 对硝基苯甲酰氯 4-NitrobenzoylChloride99% p-Nitrobenzoylchlorid 4-Nitrobenzoesäurechlorid p-Nitro Benzoyl Chloride 4-Nitro Benzoyl Chloride 對硝基苯甲醯氯 PNBC 4-Nitrobenzenecarbonyl chloride 4-硝基苯甲酰氯氯化对硝基苯甲酰 p-Nitrobenzoyl chloride; 4-Nitrobenzoylchloride; 4-Nitrobenzoic acid chloride paraNitro Benzoyl Chloride p-nitro-benzoylchlorid LABOTEST-BB LT00077260 p-Nitrobenzoyl chloride p-nitrobenzoicacidchloride 氯化对硝基苯甲酰 4-Nitrobenzoyl chloride P-NITROBENZOYL CHLORIDE
CAS Number122-04-3
EC Number204-517-4
Beilstein Registry Number473192
MDL NumberMFCD00007345
PubChem Substance ID8502
Merck Number6589
Chemical Name Translation4-硝基苯甲酰氯
Reaxys-RN473192
LabNetwork Molecule IDLN00223139
InChIInChI=1S/C7H4ClNO3/c8-7(10)5-1-3-6(4-2-5)9(11)12/h1-4H
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • {SNA} Analytical Reagents, Analytical/Chromatography, Derivatization Reagents, Derivatization Reagents HPLC, UV-VIS
  • {uni_hamburg} no charge; carbocycle; aromatic; 6RingOnly; 6ring; carbonyl chloride; 1fragment
  • {SNA} Derivatization Reagents, Derivatization Reagents HPLC, UV-VIS, 分析/色谱, 分析试剂
  • {SNA} Acid Halides, Building Blocks, Carbonyl Compounds, Chemical Synthesis, Organic Building Blocks

产品应用

  • HPLC中羟基基团的衍生化

相关文献及参考

  • Short: III/35E
  • Reagent for the preparation of crystalline esters.
  • Short: IV/1a
  • Merck: 14,6590 Beilstein:9,394
  • Short: EINECS
  • Merck: 14,6590

安全信息

Signal word Danger
GHS Symbol
WGK Germany2
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
Risk Statements
  • R34 Causes burns 会导致灼伤
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
  • P234 Keep only in original container. 只保留在原来的容器中。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P303+P361+P353+P310+P363
  • P304+P340+P310
  • P305+P351+P338
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P390 Absorb spillage to prevent material damage. 吸收溢出物，防止重大损害。
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H290 May be corrosive to metals 可能腐蚀金属。
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
RTECSDM6651000
Packing GroupII
UN Number 3261 UN 3261 8/PG 2
Storage condition Moisture Sensitive 易吸潮，密封保存 储存温度2-8℃
Hazard Codes 8 C
Hazard Class8
Warnings 危化品目录(2015) 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5600 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Behavioral - ataxia
   Behavioral - muscle contraction or spasticity
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 28(9),47,1984

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3440 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Behavioral - ataxia
   Behavioral - muscle contraction or spasticity
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 28(9),47,1984

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 4750 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Behavioral - ataxia
   Behavioral - muscle contraction or spasticity
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 28(9),47,1984

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 3 ug/plate
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 9(Suppl
   9),1,1987

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Mammal - species unspecified
DOSE                    : 11830 ug/m3/4H
SEX/DURATION            : male 16 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 28(9),47,1984

Restrict 危险品

其他信息

  • F:9-19-21
  • 毒性分级:中毒
  • MOL 文件:122-04-3.mol
  • 类别:有毒物品
  • 用途三:用作医药、染料、彩色显影剂的中间体。在医药工业中用于普鲁卡因胺盐酸盐、叶酸等的生产。
  • 急性毒性:口服-大鼠 LD50: 5600 毫克/公斤; 口服-小鼠 LD50: 3440 毫克/公斤
  • 下游产品:对硝基苯乙酮 --> 2,4-二氯氟苯 --> 氟虫腈 --> 对氨基苯甲酰胺 --> N-(4-氨基苯甲酰)-L-谷氨酸 --> 盐酸普鲁卡因胺 --> 丁胺卡因 --> N-对硝基苯甲酰谷氨酸 --> 7-氨基-3-{[(5-甲基-1,3,4-噻二唑-2-基)硫]甲基}头孢霉素烷酸 --> 金精三羧酸
  • 4-硝基苯甲酰氯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 80091126 4-硝基苯甲酰氯;对硝基苯甲酰氯; 氯化对硝基苯甲酰 100g 158元 2011/04/16 N0176 4-硝基苯甲酰氯 4-Nitrobenzoyl Chloride 500G 880元 2011/04/16 N0176 4-硝基苯甲酰氯 4-Nitrobenzoyl Chloride 25G 170元
  • 图谱信息:4-硝基苯甲酰氯(122-04-3)质谱(MS)
  • 用途一:用于医药、染料和有机合成
  • 海关编码:29163900
  • 用途二:用作医药、染料中间体
  • 用途四:用作医药；染料；彩色显影剂的中间体。在医药工业中用于普鲁卡因胺盐酸盐；叶酸等的生产。
  • TCI Shanghai:对硝基苯甲酰氯 4-Nitrobenzoyl Chloride,>;98.0%(GC)(T)(122-04-3)
  • 溶于乙醚，遇水和乙醇分解。易吸潮。
  • 储运特性:库房通风低温干燥; 与氧化剂、食品添加剂分开存放
  • MSDS 信息:4-硝基苯甲酰氯(122-04-3).msds
  • 外观性质:黄色晶状固体，有刺激气味。
  • Alfa Aesar:4-硝基苯甲酰氯,98% 4-Nitrobenzoyl chloride, 98%(122-04-3)
  • 灭火剂:二氧化碳、泡沫、砂土、干粉。
  • Acros Organics:4-硝基苯甲酰氯 4-Nitrobenzoyl chloride, 98%(122-04-3)
  • 方法一:以对硝基苯甲酸为原料，用氯化亚砜或三氯氧磷或光气进行氯化都可以制得该品。将对硝基苯甲酸和三氯氧磷加热回流24h，减压回收三氯氧磷，即生成对硝基苯甲酰氯。或将对硝基苯甲酸和氯化亚砜加热至90℃，回流30-40h，然后冷却析出对硝基本甲酰氯结晶。收率90%。将光气通入熔融的对硝基苯甲酸，将光气化反应物进行减压蒸馏，也可以获得对硝基苯甲酰氯。
  • 上游原料:氧氯化硫 --> 三氯氧磷 --> 对硝基苯甲酸
  • 可燃性危险特性:明火可燃;高热分解释放有毒氮氧化物和氯化物烟雾;与水产生腐蚀性气体
  • Sigma Aldrich:122-04-3(sigmaaldrich)
  • 敏感性:Moisture Sensitive

系列性分类

  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Reagents
  3. Derivatization Reagents 衍生分析试剂
  4. Derivatization Reagents HPLC - Derivatization Reagents
  5. UV-VIS - Derivatization Reagents HPLC
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Acid Halides 酸性卤化物(酰氯等)
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Acid Halides 酸性卤化物(酰氯等)
  1. Analytical & Chromatography 分析化学与色谱
  2. Labeling Reagents for HPLC
  1. Analytical & Chromatography 分析化学与色谱
  2. HPLC
  3. Derivatization Reagents
  4. HPLC Derivatization Reagents, by Application
  5. Thiols
  1. Analytical & Chromatography 分析化学与色谱
  2. Derivatization Reagents
  3. Derivatization Reagents HPLC
  4. HPLC Derivatization Reagents, by Application
  5. Thiols
  1. Acyl halide
  2. acyl chloride

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