O-(Benzotriazol-1-yl)-N,N,N’,N’-tetramethyluronium Tetrafluoroborate (TBTU) O-苯并三氮唑-N,N,N,N-四甲基脲四氟硼酸酯(TBTU)

CAS 125700-67-6 MFCD00077413

化学结构图

125700-67-6
SMILES: CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F

化学属性

Mol. FormulaC11H16BF4N5O
Mol. Weight321
Melting Point205
TSCANo
Density1.422
pH:A

别名和识别编码

Chemical NameO-(Benzotriazol-1-yl)-N,N,N’,N’-tetramethyluronium Tetrafluoroborate (TBTU)
Synonym N,N,N,N-Tetramethyl-O-(benzotriazol-1-yl)uronium tetrafluoroborate N,N,N′,N′-Tetramethyl-O-(benzotriazol-1-yl)uronium tetrafluoroborate TBTU TBTU 苯并三唑四甲基四氟硼酸
Beilstein Registry Number7066325
PubChem Substance ID87564559
CAS Number125700-67-6
MDL NumberMFCD00077413
Reaxys-RN7066325
EC Number423-040-4
Chemical Name TranslationO-苯并三氮唑-N,N,N,N-四甲基脲四氟硼酸酯(TBTU)
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分类

  • {SNA} Chemical Biology, Chemical Synthesis, Coupling, Peptide Chemistry, Peptide Coupling, Phosphonium/Uronium/Formamidinium, Synthetic Reagents

产品应用

  • 偶联试剂,用于固相多肽合成。

相关文献及参考

  • 1. I. Abdelmoty et al. Lett. Pept. Sci. 1 , 57, (1994)
  • I. Abdelmoty Lett. Pept. Sci. 1 , 57, (1994)
  • 2. S. Zimmer et al., C.H. Schneider and A.N. Eberle, eds. Proc. 22nd Eur. Pept. Symp.: Peptides 1992 Leiden 1993, p. 393
  • S. Zimmer, C.H. Schneider and A.N. Eberle, eds. Proc. 22nd Eur. Pept. Symp.: Peptides 1992 Leiden , (1993), 393
  • Fieser 12 ,44
  • FT-NMR 1 (3), 192:C / RegBook 1 (2), 2447:F / Structure Index 1 , 387:A:6

安全信息

Precautionary statements
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P330+P331+P310
  • P303+P361+P353
  • P303+P361+P353+P310+P363
  • P304+P340
  • P304+P340+P310
  • P305+P351+P338
  • P305+P351+P338+P310
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
WGK Germany3
GHS Symbol
Signal word Danger
Hazard statements
  • H228 Flammable solid 易燃固体
  • H302 Harmful if swallowed 吞食有害
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Hazard Codes 4.1
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
UN Number 1325 1759
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S37 Wear suitable gloves 戴适当手套;
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Storage condition Moisture Sensitive 2-8°C储存
Packing GroupII
Hazard Class8

系列性分类


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